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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Regarding whether fitness landscapes are similarly relevant in a full blown cancer

From Complex Time

Yes. Similar ideas should be relevant within a tumor, although the adaptive landscape will now mostly be dictated by the tumor microenvironment, not the “tissue microenvironment”.  Bob Gatenby and Bob Gillies (both at Moffitt) have done nice mathematical modeling for how the tumor microenvironment changes, creating new hurdles that must be cleared by adaptation.