Hallmarks of Biological Failure/BarbaraNatterson-Horowitz
Notes by user Barbara Natterson-Horowitz (Harvard) for Hallmarks of Biological Failure
Post-meeting Reflection
1+ paragraphs on any combination of the following:
- Presentation highlights
- Open questions that came up
- How your perspective changed
- Impact on your own work
- e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group
Today's lectures spanned subcellular level to ecosystems. After today I find myself increasingly in exploring whether and how well conceiving of aging as a narrowing of the range of dynamic responses to environmental change works 'below' the organismic level.
Tomorrow we will define aging---it will be important to separate what are 'wear/tear' effects (calcification, fibrosis etc etc. etc.), what are from longevity issues.
Questions:
Is there underrecognition of the role of induced developmental pathways during pre-scenescent periods on characteristics of senescence
What is and is not sound about the hypothesis that for older animals with decreasing reproductive ability, engaging in activities which improve safety and resources of the environment (which would give their preexisting offspring advantage) might induce life-extending effects. Selection for longevity potential....amplified by induction of pathways by environment/community enhancing activity.
Reference material notes
Some examples:
- Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
- Here is a free tool for calculating [ABC] (insert link)
- This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
- Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).
Reference Materials
