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1+ paragraphs on any combination of the following:
Common principles of sleep-related oscillations that subserve some form of 'learning', e.g. bursting on a background of neural quiescence - this definition would encompass the unusual features of sleep in early development. Very interested by a) Susan's reference to the Aston-Jones 1981 paper that shows attenuation immediately prior to firing as if to 'boost' the effect of the firing, b) that oscillations can occur but the ones that have many frequency bands coupled together are the most important for memory consolidation, c) Susan's quote 'synchronous activity during sleep provides a substrate for ' (the square brackets could be replaced by nearly all functions!)
Remembering: we need augmented oscillatory power for a stimulus to be learned (Sara's talk) and this can be artifically provided (Ognjanovski et al. 2018), how might this relate to augmented sleep EEG power post brain injury - is it possibly not just a biomarker of damage but a marker of the synchronised activity necessary to 're-learn' new circuits? If a neuron which has learnt something continues to stay more active, for how long? How does that link to the renormalisation mentioned in final slide?
Forgetting: Is it REM sleep or forgetting or dreaming specifically for forgetting? Very interested by Gina's reference to Crick 1983 Nature paper - how could that relate to infants who have MORE REM sleep but probably don't yet dream like we conceive dreaming
Sleep oscillations as a spatial filter: because some neuronal ensembles can't keep up with the speed of oscillations, creates a spatial filter
Cortical region specific projections from Locus Coeruleus (Chander et al. 2019 ref from Gina's talk): a way that sleep-wake states could differentially modulate sensorimotor areas in the developing brain, to help them to differentiate?
Durations of sleep: Bob's conceptual theory that 100ms of sleep would be sufficient to encode a memory e.g. a microsleep. Could that be reversed to think about some adaptive function of the extra-short WAKE durations pre-term infants have e.g. 2 minutes?
Body weight vs. age predicting sleep-wake bout durations: Following up on Geoffrey's question, I will go back to the literature to check those references that biological age is more predictive than body weight. But thinking about his question, my forthcoming project on intra-uterine growth restriction would be an ideal opportunity to look at this in more detail.
Other ways I intend to improve my practice following this meeting: report ambient temperature
Evocative metaphors!: 'Mountain of wakefulness'. Bob's 'Memory evolution', more dynamic than just consolidation which doesn't fully capture sleep's functions. 'Ground truth' - the challenges of establishing this in many aspects of sleep research