https://centre.santafe.edu/complextime/w/api.php?action=feedcontributions&user=GaganWig&feedformat=atomComplex Time - User contributions [en]2024-03-28T09:32:50ZUser contributionsMediaWiki 1.35.6https://centre.santafe.edu/complextime/w/index.php?title=Decreased_segregation_of_brain_systems_across_the_healthy_adult_lifespan&diff=4698Decreased segregation of brain systems across the healthy adult lifespan2019-07-12T04:28:57Z<p>GaganWig: Created page with "{{Reference Material |Meeting=Cognitive Regime Shift I - When the Brain Breaks |Added by=GaganWig |title=Decreased segregation of brain systems across the healthy adult lifesp..."</p>
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<div>{{Reference Material<br />
|Meeting=Cognitive Regime Shift I - When the Brain Breaks<br />
|Added by=GaganWig<br />
|title=Decreased segregation of brain systems across the healthy adult lifespan<br />
|authors=Micaela Y. Chan;Denise C. Park;Neil K. Savalia;Steven E. Petersen;Gagan S. Wig<br />
|type=journal<br />
|year=2014<br />
|source name=Proceedings of the National Academy of Sciences<br />
|issn=0027-8424<br />
|doi=10.1073/pnas.1415122111<br />
|scopus=2-s2.0-84911873040<br />
|abstract=Healthy aging has been associated with decreased specialization in brain function. This characterization has focused largely on describing age-accompanied differences in specialization at the level of neurons and brain areas. We expand this work to describe systems-level differences in specialization in a healthy adult lifespan sample (n = 210; 20-89 y). A graph-theoretic framework is used to guide analysis of functional MRI resting-state data and describe systems-level differences in connectivity of individual brain networks. Young adults' brain systems exhibit a balance of within- and between-system correlations that is characteristic of segregated and specialized organization. Increasing age is accompanied by decreasing segregation of brain systems. Compared with systems involved in the processing of sensory input and motor output, systems mediating "associative" operations exhibit a distinct pattern of reductions in segregation across the adult lifespan. Of particular importance, the magnitude of association system segregation is predictive of long-term memory function, independent of an individual's age.<br />
|Mendeley link=http://www.mendeley.com/research/decreased-segregation-brain-systems-across-healthy-adult-lifespan<br />
|month=11<br />
|day=18<br />
|pages=E4997-E5006<br />
|volume=111<br />
|issue=46<br />
|publisher=Proceedings of the National Academy of Sciences<br />
}}</div>GaganWighttps://centre.santafe.edu/complextime/w/index.php?title=Cognitive_Regime_Shift_I_-_When_the_Brain_Breaks/Large-scale_Brain_Network_Changes_Across_the_Healthy_Adult_Human_Lifespan:_Relations_to_Cognition_and_First_Steps_toward_Identifying_Potential_Risk_Factors_of_Brain_Decline&diff=1377Cognitive Regime Shift I - When the Brain Breaks/Large-scale Brain Network Changes Across the Healthy Adult Human Lifespan: Relations to Cognition and First Steps toward Identifying Potential Risk Factors of Brain Decline2018-07-31T03:53:45Z<p>GaganWig: </p>
<hr />
<div>{{Agenda item<br />
|Start time=July 24, 2018 10:50:00 AM<br />
|End time=July 24, 2018 11:40:00 AM<br />
|Presenter=GaganWig<br />
|Pre-meeting notes=-Human brain areas are organized into a large-scale functional network, which can be measured at rest using non-invasive brain imaging (functional MRI)<br />
<br />
<br />
-The brain network contains segregated sub-networks that correspond to functionally specialized brain systems<br />
<br />
<br />
-The segregation of brain systems declines with increasing age, across the healthy adult lifespan<br />
<br />
<br />
-System segregation relates to cognitive function in individuals (greater system segregation is associated with better long--term memory ability)<br />
<br />
<br />
-Certain health risk factors (e.g., lower socioeconomic status) are related to lower system segregation<br />
<br />
<br />
-My working hypothesis is that gradual and sudden cognitive decline is related to changes in system segregation as an individual ages, and that individual differences in rate and risk of decline are a consequence of the capacity of the functional brain network to tolerate and adapt to damage (neurodegeneration)<br />
|Post-meeting notes=-applying different approaches in complexity towards understanding age-related changes in brain organization (e.g., thinking about flickering, network 'clogging')<br />
<br />
<br />
-prospects of expanding/linking our work to additional scales of analysis<br />
}}</div>GaganWighttps://centre.santafe.edu/complextime/w/index.php?title=Socioeconomic_status_moderates_age-related_differences_in_the_brain%E2%80%99s_functional_network_organization_and_anatomy_across_the_adult_lifespan&diff=1160Socioeconomic status moderates age-related differences in the brain’s functional network organization and anatomy across the adult lifespan2018-07-25T18:06:18Z<p>GaganWig: Created page with "{{Reference Material |Meeting=Cognitive Regime Shift I - When the Brain Breaks |Mendeley id=98d599fc-fdda-3946-bca1-a155089826fd }}"</p>
<hr />
<div>{{Reference Material<br />
|Meeting=Cognitive Regime Shift I - When the Brain Breaks<br />
|Mendeley id=98d599fc-fdda-3946-bca1-a155089826fd<br />
}}</div>GaganWighttps://centre.santafe.edu/complextime/w/index.php?title=Review_-_Segregated_Systems_of_Human_Brain_Networks&diff=1159Review - Segregated Systems of Human Brain Networks2018-07-25T18:04:15Z<p>GaganWig: Created page with "{{Reference Material |Meeting=Cognitive Regime Shift I - When the Brain Breaks |Mendeley id=2f52c96b-5a22-3fab-8dc3-b45846e99562 }}"</p>
<hr />
<div>{{Reference Material<br />
|Meeting=Cognitive Regime Shift I - When the Brain Breaks<br />
|Mendeley id=2f52c96b-5a22-3fab-8dc3-b45846e99562<br />
}}</div>GaganWighttps://centre.santafe.edu/complextime/w/index.php?title=Cognitive_Regime_Shift_I_-_When_the_Brain_Breaks/Large-scale_Brain_Network_Changes_Across_the_Healthy_Adult_Human_Lifespan:_Relations_to_Cognition_and_First_Steps_toward_Identifying_Potential_Risk_Factors_of_Brain_Decline&diff=1155Cognitive Regime Shift I - When the Brain Breaks/Large-scale Brain Network Changes Across the Healthy Adult Human Lifespan: Relations to Cognition and First Steps toward Identifying Potential Risk Factors of Brain Decline2018-07-25T18:01:09Z<p>GaganWig: </p>
<hr />
<div>{{Agenda item<br />
|Start time=July 24, 2018 10:50:00 AM<br />
|End time=July 24, 2018 11:40:00 AM<br />
|Presenter=GaganWig<br />
|Pre-meeting notes=-Human brain areas are organized into a large-scale functional network, which can be measured at rest using non-invasive brain imaging (functional MRI)-The brain network contains segregated sub-networks that correspond to functionally specialized brain systems-The segregation of brain systems declines with increasing age, across the healthy adult lifespan-System segregation relates to cognitive function in individuals-My working hypothesis is that slow and fast cognitive decline is related to changes in system segregation as an individual ages, and that individual differences in rate and risk of decline are a consequence of the capacity to tolerate and adapt to damage to the brain network<br />
|Post-meeting notes=-im excited about applying different approaches in complexity towards understanding age-related changes in brain organization (e.g., thinking about flickering, network 'clogging'), but also relating our work across additional scales, if that is possible.<br />
}}</div>GaganWig