https://centre.santafe.edu/complextime/w/api.php?action=feedcontributions&user=TimBuchman&feedformat=atomComplex Time - User contributions [en]2024-03-29T15:52:06ZUser contributionsMediaWiki 1.35.6https://centre.santafe.edu/complextime/w/index.php?title=The_community_of_the_self3&diff=3111The community of the self32018-11-13T23:28:47Z<p>TimBuchman: Created page with "{{Reference Material |Meeting=Dynamic Multi-System Resilience in Human Aging |Added by=TimBuchman |title=The community of the self |Mendeley id=2550bf72-9b06-3375-a9e7-3c0fbdc..."</p>
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<div>{{Reference Material<br />
|Meeting=Dynamic Multi-System Resilience in Human Aging<br />
|Added by=TimBuchman<br />
|title=The community of the self<br />
|Mendeley id=2550bf72-9b06-3375-a9e7-3c0fbdc74b68<br />
}}</div>TimBuchmanhttps://centre.santafe.edu/complextime/w/index.php?title=Community_of_the_Self&diff=3110Community of the Self2018-11-13T23:27:25Z<p>TimBuchman: Created page with "{{Reference Material |Meeting=Dynamic Multi-System Resilience in Human Aging |Added by=TimBuchman |title=Community of the Self }}"</p>
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<div>{{Reference Material<br />
|Meeting=Dynamic Multi-System Resilience in Human Aging<br />
|Added by=TimBuchman<br />
|title=Community of the Self<br />
}}</div>TimBuchmanhttps://centre.santafe.edu/complextime/w/index.php?title=Dynamic_Multi-System_Resilience_in_Human_Aging/TimBuchman&diff=3107Dynamic Multi-System Resilience in Human Aging/TimBuchman2018-11-13T23:24:43Z<p>TimBuchman: </p>
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<div>{{Attendee note<br />
|Post-meeting summary=An excellent first day. We heard theory-based perspectives and came directly upon the challenges of human subjects research. The theory based perspectives from Dervis Vural, Peter Hoffmann, and Alfons Hoekstra illustrated the (relative) simplicity of models that effectively abstract and recapitulate several well-recognized characteristics of human aging and frailty. Yet human-derived data are messy, do not lend themselves easily to hypothesis testing because they are so often observational and incomplete, and are confounded by the outbred nature of humans, their varying allostatic loads, and the variety of acute-on-chronic illnesses that bring them to research studies and/or clinical care.<br />
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The most interesting part of the second day, perhaps, was the presentation on resiliency among the indigenous peoples of NM. It became quite clear that the ability to (re)generate networks and interactions was foundational to regenerating the population. A reasonable inference , and mirroring Dervis Vural's presentation on Day 1, is that the capacity to reconstruct networks is foundational to resilience. It is unclear whether it is the ability to reconstruct some evolutionarily specified or developmental network is required, or rather a more general capacity. But "fixing a failed node" is unlikely to work unless that failed node is the foundational "network spawner". <br />
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The need for a marker that reliably informs clinicians that the capacity to recover from perturbation is now (and forever) exhausted is apparent. The problem around end of life is acknowledging that it is indeed end-of-life, that the physiological derangement exceeds reparative capacity, with or without the stabilization that clinicians can provide. As technical medicine gets better at dealing with minutiae, such markers of inevitable collapse become even more important. As a reminder, 27% of the US Medicare budget is routinely spent in the last year of life, with a substantial uptick in the last month as part of the "rescue phantasy" to use Freud's term. "slowing" and delayed correction of spontaneous or engineered perurbations is a start, but seems by itself insufficient as a basis for clinical decision making.<br />
}}</div>TimBuchmanhttps://centre.santafe.edu/complextime/w/index.php?title=The_community_of_the_self2&diff=3021The community of the self22018-11-12T23:48:08Z<p>TimBuchman: Created page with "{{Reference Material |Meeting=Dynamic Multi-System Resilience in Human Aging |Added by=TimBuchman |title=The community of the self |Mendeley id=2550bf72-9b06-3375-a9e7-3c0fbdc..."</p>
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<div>{{Reference Material<br />
|Meeting=Dynamic Multi-System Resilience in Human Aging<br />
|Added by=TimBuchman<br />
|title=The community of the self<br />
|Mendeley id=2550bf72-9b06-3375-a9e7-3c0fbdc74b68<br />
|Type of meeting=General Conference<br />
|Keywords=Homeostasis<br />
}}</div>TimBuchmanhttps://centre.santafe.edu/complextime/w/index.php?title=The_community_of_the_self&diff=3016The community of the self2018-11-12T23:46:58Z<p>TimBuchman: Created page with "{{Reference Material |Meeting=Dynamic Multi-System Resilience in Human Aging |Added by=TimBuchman |title=The community of the self |Mendeley id=2550bf72-9b06-3375-a9e7-3c0fbdc..."</p>
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<div>{{Reference Material<br />
|Meeting=Dynamic Multi-System Resilience in Human Aging<br />
|Added by=TimBuchman<br />
|title=The community of the self<br />
|Mendeley id=2550bf72-9b06-3375-a9e7-3c0fbdc74b68<br />
|Keywords=homeostasis<br />
}}</div>TimBuchmanhttps://centre.santafe.edu/complextime/w/index.php?title=Uncoupling_of_biological_oscillators:_A_complementary_hypothesis_concerning_the_pathogenesis_of_multiple_organ_dysfunction_syndrome&diff=3015Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome2018-11-12T23:45:54Z<p>TimBuchman: Created page with "{{Reference Material |Meeting=Dynamic Multi-System Resilience in Human Aging |title=Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesi..."</p>
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<div>{{Reference Material<br />
|Meeting=Dynamic Multi-System Resilience in Human Aging<br />
|title=Uncoupling of biological oscillators: A complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome<br />
|Mendeley id=52399c27-1e5c-3cc1-96a1-ec2df34388b9<br />
|Type of meeting=General Conference<br />
|Keywords=multiple organ dysfunction<br />
}}</div>TimBuchmanhttps://centre.santafe.edu/complextime/w/index.php?title=Uncoupling_of_Biological_Oscillators&diff=3007Uncoupling of Biological Oscillators2018-11-12T23:43:24Z<p>TimBuchman: Created page with "{{Reference Material |Meeting=Dynamic Multi-System Resilience in Human Aging |Added by=TimBuchman |title=Uncoupling of Biological Oscillators }}"</p>
<hr />
<div>{{Reference Material<br />
|Meeting=Dynamic Multi-System Resilience in Human Aging<br />
|Added by=TimBuchman<br />
|title=Uncoupling of Biological Oscillators<br />
}}</div>TimBuchmanhttps://centre.santafe.edu/complextime/w/index.php?title=Dynamic_Multi-System_Resilience_in_Human_Aging/TimBuchman&diff=2988Dynamic Multi-System Resilience in Human Aging/TimBuchman2018-11-12T23:29:45Z<p>TimBuchman: Created page with "{{Attendee note |Post-meeting summary=An excellent first day. We heard theory-based perspectives and came directly upon the challenges of human subjects research. The theory b..."</p>
<hr />
<div>{{Attendee note<br />
|Post-meeting summary=An excellent first day. We heard theory-based perspectives and came directly upon the challenges of human subjects research. The theory based perspectives from Dervis Vural, Peter Hoffmann, and Alfons Hoekstra illustrated the (relative) simplicity of models that effectively abstract and recapitulate several well-recognized characteristics of human aging and frailty. Yet human-derived data are messy, do not lend themselves easily to hypothesis testing because they are so often observational and incomplete, and are confounded by the outbred nature of humans, their varying allostatic loads, and the variety of acute-on-chronic illnesses that bring them to research studies and/or clinical care.<br />
}}</div>TimBuchman