Difference between revisions of "Aging and Adaptation in Infectious Diseases/AndrewPDobson"

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Notes by user Andrew P. Dobson (Princeton) for Aging and Adaptation in Infectious Diseases

Post-meeting Reflection

1+ paragraphs on any combination of the following:

Presentation highlights

Open questions that came up

How your perspective changed

Impact on your own work

e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

Really interesting set of talks that blended into a good set of discussions on projects the group could work on. There will be a big emphasis on human immunity and how it first gains 'experience' and then breaks down with age.

I'm likely to focus my attention on developing body sized scaled models for immune system. These could be both fairly simple models for immunity mainly capturing differences between Type I and Type II immunity, but then expanding this to take Jean Carlson's model for human immunity and rescale elements of this with host body size and BMR.

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Reference material notes

Some examples:

Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).

Here is a free tool for calculating [ABC] (insert link)

This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!

Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).

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Reference Materials

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Presenter on the following Agenda items

Session IV: Complex Rhythms, environment, and aging in epidemiology

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 {{Attendee note
-|Post-meeting summary=Assemble a talk that describes non-human examples of how host exposure and response to pathogens and disease changes with age.
+|Post-meeting summary=Really interesting set of talks that blended into a good set of discussions on projects the group could work on. There will be a big emphasis on human immunity and how it first gains 'experience' and then breaks down with age.
-Describe ways of quantifying age-dependent changes in exposure.
+I'm likely to focus my attention on developing body sized scaled models for immune system. These could be both fairly simple models for immunity mainly capturing differences between Type I and Type II immunity, but then expanding this to take Jean Carlson's model for human immunity and rescale elements of this with host body size and BMR.
-Discuss possible dynamic consequences in variation in duration of incubation and infectivity with age.
-Describe models for parasitic nematodes of different sizes living as a community of worms in hosts of different sizes.
-Illustrate recent work with Ian Hatton on body size scaling of vital rates from Algae to Elephants - use this to suggest we could use this scaling for models of immune system in mammals (from bats and mice to elephants and whales).
 }}

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