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Aging and Adaptation in Infectious Diseases II/Session I: Immune System: Architecture and Dynamics

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April 30, 2019
9:30 am - 12:00 pm

Chair

Mercedes Pascual (Univ. Chicago)

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Universal laws and architectures in complex networked systems with applications to aging and immune systems
Presenter
John Doyle (Caltech)

Abstract

Effective layered architectures such as in brains and organisms seamlessly integrate high level goal and decision making and planning with fast lower level sensing, reflex, and action and facilitate learning, adaptation, augmentation (tools), and teamwork, while maintaining internal homeostasis.  This is all despite the severe demands such actions can put on the whole body’s physiology, and despite being implemented in highly energy efficient hardware that has distributed, sparse, quantized, noisy, delayed, and saturating sensing, communications, computing, and actuation. Similar layering extends downward into the cellular level, out into ecological and social systems, and many aspects of this convergent evolution will increasingly dominate our most advanced technologies. Simple demos using audience’s brains can highlight universal laws and architectures and their relevance to tech, bio, neuro, med, and social networks.  This suggests conjectures about senescence, and tradeoffs in the evolution of cancer, wound healing, degenerative diseases, auto-immunity, parasitism, and social organization, and potential animal models to explore these tradeoffs.

With this motivation, we’ll sketch progress on a new unified theory of complex networks that integrates communications, control, and computation with applications to cyberphysical systems as well as neuroscience and biology.  Though based on completely different constraints arising from different environments, functions, and hardware, such systems face universal tradeoffs (laws) in dimensions such as efficiency, robustness, security, speed, flexibility, and evolvability. And successful systems share remarkable universals in architecture, including layering, localization, and diversity sweet spots, to effectively manage these tradeoffs, as well as universal fragilities, particularly to infectious hijacking. 

I have videos of some introductory material and posted it in my public dropbox folder:

https://www.dropbox.com/sh/7bgwzqsl7ycxhie/AABQB9L2J-XmCniwgyO3N83Ba?dl=0

Some new neuro stuff (with videos) is in the subfolder  1.New_CDS141\2.2.UCSDneuro

There are lots of videos and papers on biology and medicine (and lots of tech) in the subfolder 0.Intro2Research.

Given the limited time and that I’m an extreme outlier, I’ll try to post videos (need to organize them) of some additional background material on aging, cancer, immune systems, wound healing, microbiome, etc that give some background on our approach to these topics.

Some videos/slides relevant to this meeting are in the subfolder: 1.New_CDS141\4.2.AgingSFI    

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Allometric Scalings and Immune Dynamics
Presenter
Andrew P. Dobson (Princeton)
Chris Kempes (SFI)


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Kempes-Slides-4-30-1019.pdf (x)

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Immunosenescence in Coupled Innate/Adaptive Immune Architecture
Presenter
Eric Jones (UCSB)
Jean Carlson (UCSB)

Abstract

The innate and adaptive components of the immune system do not age independently. We consider a mathematical model that couples these two complementary responses, and demonstrate a mechanism in which the progression of immunosenescence in the adaptive response leads to aging in the inflammatory response. We analyze the innate-adaptive interface of this coupled immune model by studying cytomegalovirus infection, a persistent infection that interacts with both components of the immune system.    

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Specific and generalized immunity in rotavirus multi-strain dynamics
Presenter
Pamela Martinez (Harvard)


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