Difference between revisions of "Cognitive Regime Shift I - When the Brain Breaks/"Prion dynamics and latency""
Line 7: | Line 7: | ||
− | + | Some very general issues that arose in conversation that require further exploration include: | |
− | + | # Approaching disease from a first-principles theoretical perspective - as is common in ecology - thus establishing principled data collection objectives (this would require a rigorous operational definition of the disease state in formal terms) | |
− | Some very general issues that arose in conversation that require further exploration include: | + | # The value and limitation of the current inductive, big data approach, that focuses on time-dependent associations |
− | + | # The meaning of cognitive reserve, exercise or error correction, and the limits to these | |
− | + | # How adaptive phenomena that are ongoing mitigate the disease state or at some point perhaps accelerate it. | |
− | + | # How we might better explore causality in large systems with extensive non-linear feedback mechanisms. | |
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
}} | }} |
Revision as of 05:27, July 26, 2018
July 23, 2018
1:30 pm - 2:20 pm
- Presenter
David Krakauer (SFI)
- Abstract
A large number of neurodegenerative diseases feature the accumulation of mis-folded proteins. These include prion diseases, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. In all of these cases several different scales of organization are associated with disease progression or onset to include genetic, epigenetic, neural circuits, brain modules, and behavior. How should we best integrate data from each of these levels and what models and theories allow us to span levels? I shall discuss a few dynamical models of polymerization, protein accumulation, and protein diffusion through neural connections, that provide insights into disease progression at a number of different time and space scales. An ongoing challenge is a criterion for fixing thresholds that define an observable cognitive regime shift.
- Presentation file(s)
- Related files