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Dynamic Multi-System Resilience in Human Aging/Emergence of Aging in Natural and Synthetic Multicellular Structures

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November 12, 2018
10:00 am - 10:40 am


Dervis Can Vural (Univ. Notre Dame)


Many simple organisms such as ferns, hydra orjellyfish do not age. Their mortality rates remain approximately constant atall ages. In contrast, complex organisms typically have a probability of deathm(t)thatincreases with age, t. Furthermore, the functional form of m(t) for manydifferent organisms show a remarkable degree of similarity. The differencebetween simple and complex organisms, and the universality of aging patternsamong complex organisms strongly suggest that aging is an emergent phenomenonthat depends not on the individual properties of biological building blocks,but rather, on the interactions between them. Indeed, we die not because weslowly run out of live cells, but because of systemic failures that manifest incomplex organs. In this talk I will present a quantitative theory of agingbased on evolutionary and mechanical arguments, and show how aging appears asan emergent phenomenon as one moves across the scale of complexity, from largemolecules and cells, to tissues and organs. I will particularly focus on agingin synthetic tissues, since this is the simplest structure that admitscontrolled experimental observation of emergent systemic damage.<o:p></o:p>

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