Emergent Functional Network Effects in Parkinson Disease
- Category
- General Reference
- author-supplied keywords
- keywords
- authors
- Caterina Gratton
- Jonathan M. Koller
- William Shannon
- Deanna J. Greene
- Baijayanta Maiti
- Abraham Z. Snyder
- Steven E. Petersen
- Joel S. Perlmutter
- Meghan C. Campbell
- title
- Emergent Functional Network Effects in Parkinson Disease
- type
- journal
- year
- 2019
- source
- Cerebral cortex (New York, N.Y. : 1991)
- pages
- 1701
- volume
- 29
- issue
- 4
- publisher
- NLM (Medline)
Abstract
A sensitive, precise and accurate quantitative liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the measurement of erythromycin A (EA) and related substances in commercial samples was developed and validated. The samples were chromatographed on a reversed-phase column with a polar endcapping and analyzed by ion trap tandem mass spectrometry in the multiple reaction monitoring (MRM) mode using positive electrospray ionization. The method showed high recovery (>98.82%), high sensitivity (lower limit of quantitation of 0.25 ng/mL for EA and less than 7.3 ng/mL for the related substances) and high precision (<0.52%) as well as excellent linearity (r2 > 0.991) with a run time of only 13 min. The method was successfully applied to the determination of EA and related substances in commercial samples. Moreover, using the advanced data-dependent acquisition capability of the ion trap software two new unexpected EA related substances could be detected and possible structures for these substances were postulated. © 2006 Elsevier B.V. All rights reserved.
Counts
- Citation count From Scopus. Refreshed every 5 days.
- Page views
- 6
Identifiers
- doi: 10.1093/cercor/bhy229 (Google search)
- issn: 14602199
- sgr: 85062991802
- scopus: 2-s2.0-85062991802
- pui: 626804443
