Hallmarks of Biological Failure/DanielPromislow
Notes by user Daniel Promislow (Univ. Washington) for Hallmarks of Biological Failure
1+ paragraphs on any combination of the following:
- Presentation highlights
- Open questions that came up
- How your perspective changed
- Impact on your own work
- e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group
Apr 8, 2019
A few thoughts about general questions for discussion:
- What do we mean by "Biological Failure"? Aging? Senescence?
- Is there such a thing as a truly non-aging organism? An immortal organism?
- Things that change with age...
- Why do so many things appear to increase exponentially, and in parallel on a log-linear scale, with age?
- Are there commonalities across other levels of organization with respect to how things change with age, and by 'things', this could be function, or selection, or failure.
- What maintains variance among populations in aging. Even after controlling for G and E, we still see high levels of variance.
- Issues of complexity/simplicity and networks were touched upon today, but we have not yet gone into detail, discussing this.
Suggestions idea that complexity can be bad. We can think of organismal organization (and function and failure?) in a two-dimensional space of couple (loose<-->tight) and complexity (linear<-->high). Berni suggests (I think) that biological entities with high complexity (brains, immune system) are more prone to bring the entire system down with failure. Entities that are simple and loosely coupled are less likely to fail badly. Suggests a negative correlation between senescence and intelligence, though the GWAS data supporting this are problematic (like the recent study claiming to find genes for SES--https://www.biorxiv.org/content/10.1101/457515v1) are likely due to social stratification. Bernie's neologism of the day: badaptation.
Comparative analysis of annual life history in killifish. Would benefit from Nathan Clark approach to look at rates of protein evolution in annual/perennial species: https://elifesciences.org/articles/25884. Expansion of mitochondrial genome is striking. I wonder if the finding of increase in genome size in the annual species is true of annual plant species (like corn and rice, which have very large genomes) relative to perennial plants.
Notion of adaptive oncogenesis, with stem cells well adapted to niche. As tissue ages, stem cells are no longer well adapted to the niche in which they find themselves. I wonder whether these models are also relevant to the selection process that happens *within* a tumor once cancer growth (and mutator phenotypes) is underway.
Reference material notes
- Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
- Here is a free tool for calculating [ABC] (insert link)
- This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
- Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).