https://centre.santafe.edu/complextime/w/index.php?title=Hallmarks_of_Biological_Failure/MariaRiolo&feed=atom&action=historyHallmarks of Biological Failure/MariaRiolo - Revision history2024-03-29T09:21:36ZRevision history for this page on the wikiMediaWiki 1.35.6https://centre.santafe.edu/complextime/w/index.php?title=Hallmarks_of_Biological_Failure/MariaRiolo&diff=4259&oldid=prevMariaRiolo at 22:58, April 9, 20192019-04-09T22:58:50Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging as changing that landscape and thus the probability of transitions between states. Even if we just looked at aging as a plain old flattening of the landscape (or accumulation of noise in the landscape/transition probs?), that would already pop out properties like breakdown of homeostasis/loss of resilience to perturbations (previously attracting basins aren't as steep) and a propensity to reach regimes that were previously hard to get to (e.g. cancers). At first glance it seems like flattening the landscape would lead to more variability across the board, more wide excursions to various states, but maybe that's not quite right - I could also picture a scenario where loss of local variability -> landscape dominated by broad features that haven't eroded away -> loss of diversity/flexibility, effectively being left with a small set of wide highways instead of a larger set of little paths.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging as changing that landscape and thus the probability of transitions between states. Even if we just looked at aging as a plain old flattening of the landscape (or accumulation of noise in the landscape/transition probs?), that would already pop out properties like breakdown of homeostasis/loss of resilience to perturbations (previously attracting basins aren't as steep) and a propensity to reach regimes that were previously hard to get to (e.g. cancers). At first glance it seems like flattening the landscape would lead to more variability across the board, more wide excursions to various states, but maybe that's not quite right - I could also picture a scenario where loss of local variability -> landscape dominated by broad features that haven't eroded away -> loss of diversity/flexibility, effectively being left with a small set of wide highways instead of a larger set of little paths.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Related idea today: how do "near flat until sudden acceleration of risk" disease incidence v age curves arise from more gradually creeping molecular aging? Possible mechanism could be that idea of gradual landscape change leading to a threshold where falling out of the basin of attraction becomes much more likely. <del class="diffchange diffchange-inline">Toy </del>model over lunch: stochastic logistic growth process with gradually declining carrying capacity. What do survival times look like? Turns out they do get that nice elbow property - could imaging evolving how much you invest in repairs to slow the gradual decline tuning that elbow to an appropriate age of "I probably already died by other causes and my expected # of future offspring is low."</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Related idea <ins class="diffchange diffchange-inline">came up </ins>today: how do "near flat until sudden acceleration of risk" disease incidence v age curves arise from more gradually creeping molecular aging? Possible mechanism could be that idea of gradual landscape change leading to a threshold where falling out of the basin of attraction becomes much more likely. <ins class="diffchange diffchange-inline">I tried a toy </ins>model over lunch: stochastic logistic growth process with gradually declining carrying capacity. What do survival times look like? Turns out they do get that nice elbow property - could imaging evolving how much you invest in repairs to slow the gradual decline tuning that elbow to an appropriate age of "I probably already died by other causes and my expected # of future offspring is low."</div></td></tr>
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</table>MariaRiolohttps://centre.santafe.edu/complextime/w/index.php?title=Hallmarks_of_Biological_Failure/MariaRiolo&diff=4240&oldid=prevMariaRiolo at 22:48, April 9, 20192019-04-09T22:48:53Z<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:48, April 9, 2019</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l2" >Line 2:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging as changing that landscape and thus the probability of transitions between states. Even if we just looked at aging as a plain old flattening of the landscape (or accumulation of noise in the landscape/transition probs?), that would already pop out properties like breakdown of homeostasis/loss of resilience to perturbations (previously attracting basins aren't as steep) and a propensity to reach regimes that were previously hard to get to (e.g. cancers). At first glance it seems like flattening the landscape would lead to more variability across the board, more wide excursions to various states, but maybe that's not quite right - I could also picture a scenario where loss of local variability -> landscape dominated by broad features that haven't eroded away -> loss of diversity/flexibility, effectively being left with a small set of wide highways instead of a larger set of little paths.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging as changing that landscape and thus the probability of transitions between states. Even if we just looked at aging as a plain old flattening of the landscape (or accumulation of noise in the landscape/transition probs?), that would already pop out properties like breakdown of homeostasis/loss of resilience to perturbations (previously attracting basins aren't as steep) and a propensity to reach regimes that were previously hard to get to (e.g. cancers). At first glance it seems like flattening the landscape would lead to more variability across the board, more wide excursions to various states, but maybe that's not quite right - I could also picture a scenario where loss of local variability -> landscape dominated by broad features that haven't eroded away -> loss of diversity/flexibility, effectively being left with a small set of wide highways instead of a larger set of little paths.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Related idea today: how do "near flat until sudden acceleration of risk" disease incidence v age curves arise from more gradually creeping molecular aging? Possible mechanism could be that idea of gradual landscape change leading to a threshold where falling out of the basin of attraction becomes much more likely. Toy model over lunch: stochastic logistic growth process with gradually declining carrying capacity. What do survival times look like?</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Related idea today: how do "near flat until sudden acceleration of risk" disease incidence v age curves arise from more gradually creeping molecular aging? Possible mechanism could be that idea of gradual landscape change leading to a threshold where falling out of the basin of attraction becomes much more likely. Toy model over lunch: stochastic logistic growth process with gradually declining carrying capacity. What do survival times look like? <ins class="diffchange diffchange-inline">Turns out they do get that nice elbow property - could imaging evolving how much you invest in repairs to slow the gradual decline tuning that elbow to an appropriate age of "I probably already died by other causes and my expected # of future offspring is low."</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Fraction-surviving.png|thumb]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Fraction-surviving.png|thumb]]</div></td></tr>
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</table>MariaRiolohttps://centre.santafe.edu/complextime/w/index.php?title=Hallmarks_of_Biological_Failure/MariaRiolo&diff=4235&oldid=prevMariaRiolo at 22:46, April 9, 20192019-04-09T22:46:01Z<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:46, April 9, 2019</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Attendee note</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Attendee note</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging as changing that landscape and thus the probability of transitions between states. Even if we just looked at aging as a plain old flattening of the landscape (or accumulation of noise in the landscape/transition probs?), that would already pop out properties like breakdown of homeostasis/loss of resilience to perturbations (previously attracting basins aren't as steep) and a propensity to reach regimes that were previously hard to get to (e.g. cancers). At first glance it seems like flattening the landscape would lead to more variability across the board, more wide excursions to various states, but maybe that's not quite right - I could also picture a scenario where loss of local variability -> landscape dominated by broad features that haven't eroded away -> loss of diversity/flexibility, effectively being left with a small set of wide highways instead of a larger set of little paths.</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging as changing that landscape and thus the probability of transitions between states. Even if we just looked at aging as a plain old flattening of the landscape (or accumulation of noise in the landscape/transition probs?), that would already pop out properties like breakdown of homeostasis/loss of resilience to perturbations (previously attracting basins aren't as steep) and a propensity to reach regimes that were previously hard to get to (e.g. cancers). At first glance it seems like flattening the landscape would lead to more variability across the board, more wide excursions to various states, but maybe that's not quite right - I could also picture a scenario where loss of local variability -> landscape dominated by broad features that haven't eroded away -> loss of diversity/flexibility, effectively being left with a small set of wide highways instead of a larger set of little paths.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Related idea today: how do "near flat until sudden acceleration of risk" disease incidence v age curves arise from more gradually creeping molecular aging? Possible mechanism could be that idea of gradual landscape change leading to a threshold where falling out of the basin of attraction becomes much more likely. Toy model over lunch: stochastic logistic growth process with gradually declining carrying capacity. What do survival times look like?</ins></div></td></tr>
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</table>MariaRiolohttps://centre.santafe.edu/complextime/w/index.php?title=Hallmarks_of_Biological_Failure/MariaRiolo&diff=4208&oldid=prevMariaRiolo: Created page with "{{Attendee note |Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging..."2019-04-09T01:16:58Z<p>Created page with "{{Attendee note |Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging..."</p>
<p><b>New page</b></p><div>{{Attendee note<br />
|Post-meeting summary=Interesting conceptual idea organisms traversing a state space with multiple local attractors and one absorbing state (death), and aging as changing that landscape and thus the probability of transitions between states. Even if we just looked at aging as a plain old flattening of the landscape (or accumulation of noise in the landscape/transition probs?), that would already pop out properties like breakdown of homeostasis/loss of resilience to perturbations (previously attracting basins aren't as steep) and a propensity to reach regimes that were previously hard to get to (e.g. cancers). At first glance it seems like flattening the landscape would lead to more variability across the board, more wide excursions to various states, but maybe that's not quite right - I could also picture a scenario where loss of local variability -> landscape dominated by broad features that haven't eroded away -> loss of diversity/flexibility, effectively being left with a small set of wide highways instead of a larger set of little paths.<br />
}}</div>MariaRiolo