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Hallmarks of Biological Failure/ShripadTuljapurkar

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Notes by user Shripad Tuljapurkar (Stanford) for Hallmarks of Biological Failure

Post-meeting Reflection

1+ paragraphs on any combination of the following:

  • Presentation highlights
  • Open questions that came up
  • How your perspective changed
  • Impact on your own work
  • e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

Reference material notes

Some examples:

  • Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
  • Here is a free tool for calculating [ABC] (insert link)
  • This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
  • Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).

1) Haworth et al show that heritability of a well-defined measure of cognition (hence related to the vaguer concept of IQ) changes with age. Such studies are more reliable than GWAS modeling.

2) Steiner & me show that there is lot of non-genetic heterogeneity in complex life cycles, and how to compute it

3) Steinsaltz & Evans show that stochastic"reliability" models of complex systems do NOT lead to particular "generic" patterns of failure. E.g., we don't get Gompertz from reliability models. Humans are not cars!

4) Etges et al show that genes act as clustered networks that change with age -- see

Etges, W. J., Trotter, M. V., de Oliveira, C. C., Rajpurohit, S., Gibbs, A. G., and Tuljapurkar, S. (2015). Deciphering life history transcriptomes in different environments. Molecular ecology, 24(1):151–179.

Reference Materials

Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
Neutral theory for life histories 0 7
The heritability of general cognitive ability increases linearly from childhood to young adulthood Molecular Psychiatry 2010 0 6
Markov mortality models: Implications of quasistationarity and varying initial distributions Theoretical Population Biology 2004 0 1