Irreversible Processes in Ecological Evolution/Pathogen diversity and negative frequency-dependent selection: consequences for intervention
January 29, 2019
10:00 am - 11:00 am
- Presenter
Pamela Martinez (Harvard)
- Abstract
Understanding how populations respond to selective pressures is an active area of research, of particular relevance for pathogens, which often adapt after the implementation of epidemic control strategies. Yet attempts to anticipate how and when these populations will evolve, are challenging. By looking at population diversity of rotavirus and Streptococcus pneumoniae, we have explored the impact of negative-frequency dependent selection, which tends to confer an advantage to the rare and a disadvantage to the common, in the response to intervention. Our results emphasize the resilience to control measures, and thus low vaccine effectiveness, in pathogens for which frequency-dependent selection is a key driving force.
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Reference Material
| Title | Author name | Source name | Year | Citation count From Scopus. Refreshed every 5 days. | Page views | Related file |
|---|---|---|---|---|---|---|
| Differential and enhanced response to climate forcing in diarrheal disease due to rotavirus across a megacity of the developing world | Proceedings of the National Academy of Sciences | 2016 | 0 | 0 | ||
| Prediction of post-vaccine population structure of Streptococcus pneumoniae using accessory gene frequencies | bioRxiv | 2018 | 0 | 1 | ||
| Frequency-dependent selection in vaccine-associated pneumococcal population dynamics | Nature Ecology and Evolution | 2017 | 0 | 0 |
