View source for Life-Span, tumor incidence, and natural killer cell activity in mice selected for high or low antibody responsiveness

{{Reference Material
|Meeting=Aging and Adaptation in Infectious Diseases II
|Added by=AndreaLGraham
|title=Life-Span, tumor incidence, and natural killer cell activity in mice selected for high or low antibody responsiveness
|Related files=Covelli 1984 J National Cancer Insti.pdf;
|type=journal
|year=1984
|source name=Journal of the National Cancer Institute
|issn=14602105
|sgr=0021271493
|doi=10.1093/jnci/72.5.1127
|scopus=2-s2.0-0021271493
|pui=445377276
|abstract=Biozzi mice selected for high (H) or low (L) antibody responsiveness to natural antigens have been followed for their entire life-span to examine their pathology at death. As previously found in selection I, shorter life-span and higher lymphoma incidence were observed in L responder mice than in H responder mice selected for antibody responsiveness to sheep red blood cells (selection II). In mice selected for antibody responsiveness to Salmonella flagellar antigens (selection III), similar life-span and similar lymphoma incidence were found in H and L responder mice. Natural killer (NK) cell activity, as assessed in spleen cells from young mice, was lower in L than in H responder mice of selection I but higher in L than in H responder mice of both selections II and III. All these results indicate that longevity and lymphoma incidence at death are independent of NK cell activity in mice selected for H or L antibody responsiveness to natural antigens. Furthermore, genetic selection for antibody responsiveness does not always appear to influence life-span and lymphoma incidence.
|Mendeley link=http://www.mendeley.com/research/lifespan-tumor-incidence-natural-killer-cell-activity-mice-selected-high-low-antibody-responsiveness
|pages=1127-1136
|volume=72
|issue=5
}}