Life-Span, tumor incidence, and natural killer cell activity in mice selected for high or low antibody responsiveness
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- Life-Span, tumor incidence, and natural killer cell activity in mice selected for high or low antibody responsiveness
- Journal of the National Cancer Institute
Biozzi mice selected for high (H) or low (L) antibody responsiveness to natural antigens have been followed for their entire life-span to examine their pathology at death. As previously found in selection I, shorter life-span and higher lymphoma incidence were observed in L responder mice than in H responder mice selected for antibody responsiveness to sheep red blood cells (selection II). In mice selected for antibody responsiveness to Salmonella flagellar antigens (selection III), similar life-span and similar lymphoma incidence were found in H and L responder mice. Natural killer (NK) cell activity, as assessed in spleen cells from young mice, was lower in L than in H responder mice of selection I but higher in L than in H responder mice of both selections II and III. All these results indicate that longevity and lymphoma incidence at death are independent of NK cell activity in mice selected for H or L antibody responsiveness to natural antigens. Furthermore, genetic selection for antibody responsiveness does not always appear to influence life-span and lymphoma incidence.
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- doi: 10.1093/jnci/72.5.1127 (Google search)
- issn: 14602105
- sgr: 0021271493
- scopus: 2-s2.0-0021271493
- pui: 445377276