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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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"%3AAbstract%2FA-20sensitive%2C-20precise-20and-20accurate-20quantitative-20liquid-20chromatography-2Ftandem-20mass-20spectrometry-20%28LC-2FMS-2FMS%29-20method-20for-20the-20measurement-20of-20erythromycin-20A-20%28EA%29-20and-20related-20substances-20in-20commercial-20samples-20was-20developed-20and-20validated.-20The-20samples-20were-20chromatographed-20on-20a-20reversed-2Dphase-20column-20with-20a-20polar-20endcapping-20and-20analyzed-20by-20ion-20trap-20tandem-20mass-20spectrometry-20in-20the-20multiple-20reaction-20monitoring-20%28MRM%29-20mode-20using-20positive-20electrospray-20ionization.-20The-20method-20showed-20high-20recovery-20%28-3E98.82-25%29%2C-20high-20sensitivity-20%28lower-20limit-20of-20quantitation-20of-200.25-20ng-2FmL-20for-20EA-20and-20less-20than-207.3-20ng-2FmL-20for-20the-20related-20substances%29-20and-20high-20precision-20%28-3C0.52-25%29-20as-20well-20as-20excellent-20linearity-20%28r2-20-3E-200.991%29-20with-20a-20run-20time-20of-20only-2013-20min.-20The-20method-20was-20successfully-20applied-20to-20the-20determination-20of-20EA-20and-20related-20substances-20in-20commercial-20samples.-20Moreover%2C-20using-20the-20advanced-20data-2Ddependent-20acquisition-20capability-20of-20the-20ion-20trap-20software-20two-20new-20unexpected-20EA-20related-20substances-20could-20be-20detected-20and-20possible-20structures-20for-20these-20substances-20were-20postulated.-20%C2%A9-202006-20Elsevier-20B.V.-20All-20rights-20reserved." contains a listed "%" character as part of the property label and has therefore been classified as invalid.

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