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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Contact: Caitlin Lorraine McShea, Program Manager, cmcshea@santafe.edu

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"%3AAbstract%2FAging-20leads-20to-20changes-20in-20the-20relative-20proportions-20of-20several-20functionally-20distinct-20T-20cell-20subsets%2C-20including-20increases-20in-20the-20proportions-20of-20memory-20cells-20in-20the-20CD4-20and-20CD8-20subsets-20and-20in-20the-20proportion-20of-20T-20cells-20expressing-20the-20multiple-2Ddrug-20resistance-20pump-20P-2Dglycoprotein.-20To-20see-20whether-20inspanidual-20differences-20in-20T-20cell-20subset-20levels-20predict-20life-20span%2C-20we-20measured-20the-20levels-20of-20five-20age-2Dsensitive-20T-20cell-20subsets%2C-20at-208-20and-20again-20at-2018-20months-20of-20age%2C-20in-20the-20peripheral-20blood-20of-20genetically-20heterogeneous-20mice-20bred-20as-20the-20progeny-20of-20CB6F1-20females-20and-20C3D2F1-20males.-20The-20strongest-20immunological-20predictor-20of-20life-20span-20in-20univariate-20regression-20analyses-20was-20the-20proportion-20of-20CD4-20memory-20cells-20measured-20at-2018-20months-20of-20age-20%28P%3D0.003%29.-20CD4-20memory-20cell-20levels-20remained-20strongly-20correlated-20with-20life-20span-20%28P-3C0.0003%29-20in-20a-20multiple-20regression-20analysis-20after-20adjustment-20for-20sex.-20The-20proportion-20of-20CD4-20cells-20expressing-20P-2Dglycoprotein-20was-20also-20correlated-20with-20life-20span-20%28P-3C0.01%29%2C-20but-20only-20in-20male-20mice.-20Weaker-20relationships-20were-20observed-20between-20life-20span-20and-208-2Dmonth-20tests-20of-20CD8-20memory-20and-20CD8-20P-2Dglycoprotein-20levels%2C-20for-20CD4-20naive-20cells-20at-2018-20months%2C-20and-20for-20the-20change-20in-20CD4-20naive-20cells-20between-208-20and-2018-20months-20of-20age-3B-20these-20were%2C-20however%2C-20near-20the-20margin-20of-20statistical-20significance-20and-20could-20reflect-20chance-20relationships.-20The-20relationship-20between-20CD4-20memory-20cell-20levels-20and-20life-20span-20was-20similarly-20strong-20regardless-20of-20the-20cause-20of-20death-20in-20mice-20whose-20death-20was-20attributable-20to-20lymphoma%2C-20fibrosarcoma%2C-20mammary-20carcinoma%2C-20and-20other-20forms-20of-20terminal-20pathology.-20Additional-20work-20is-20needed-20to-20discriminate-20between-20two-20hypotheses%3A-201%29-20that-20high-20levels-20of-20CD4-20memory-20cell-20themselves-20predispose-20to-20disease-20and-20early-20death%2C-20particularly-20from-20neoplasia-3B-20or-202%29-20that-20accumulation-20of-20CD4-20memory-20cells-20is-20a-20biomarker-20of-20some-20underlying-20process-2Dperhaps-20accelerated-20aging-2Dthat-20itself-20leads-20to-20early-20mortality." contains a listed "%" character as part of the property label and has therefore been classified as invalid.

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