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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Contact: Caitlin Lorraine McShea, Program Manager, cmcshea@santafe.edu

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"%3AAbstract%2FBiozzi-20mice-20selected-20for-20high-20%28H%29-20or-20low-20%28L%29-20antibody-20responsiveness-20to-20natural-20antigens-20have-20been-20followed-20for-20their-20entire-20life-2Dspan-20to-20examine-20their-20pathology-20at-20death.-20As-20previously-20found-20in-20selection-20I%2C-20shorter-20life-2Dspan-20and-20higher-20lymphoma-20incidence-20were-20observed-20in-20L-20responder-20mice-20than-20in-20H-20responder-20mice-20selected-20for-20antibody-20responsiveness-20to-20sheep-20red-20blood-20cells-20%28selection-20II%29.-20In-20mice-20selected-20for-20antibody-20responsiveness-20to-20Salmonella-20flagellar-20antigens-20%28selection-20III%29%2C-20similar-20life-2Dspan-20and-20similar-20lymphoma-20incidence-20were-20found-20in-20H-20and-20L-20responder-20mice.-20Natural-20killer-20%28NK%29-20cell-20activity%2C-20as-20assessed-20in-20spleen-20cells-20from-20young-20mice%2C-20was-20lower-20in-20L-20than-20in-20H-20responder-20mice-20of-20selection-20I-20but-20higher-20in-20L-20than-20in-20H-20responder-20mice-20of-20both-20selections-20II-20and-20III.-20All-20these-20results-20indicate-20that-20longevity-20and-20lymphoma-20incidence-20at-20death-20are-20independent-20of-20NK-20cell-20activity-20in-20mice-20selected-20for-20H-20or-20L-20antibody-20responsiveness-20to-20natural-20antigens.-20Furthermore%2C-20genetic-20selection-20for-20antibody-20responsiveness-20does-20not-20always-20appear-20to-20influence-20life-2Dspan-20and-20lymphoma-20incidence." contains a listed "%" character as part of the property label and has therefore been classified as invalid.

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