This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

List of results

• Effects of host heterogeneity on pathogen diversity and evolution  + (Phenotypic variation is common in most pat … Phenotypic variation is common in most pathogens, yet the mechanisms that maintain this diver- sity are still poorly understood. We asked whether continuous host variation in susceptibility helps maintain phenotypic variation, using experiments conducted with a baculovirus that infects gypsy moth (Lymantria dispar) larvae. We found that an empirically observed tradeoff between mean transmission rate and variation in transmission, which results from host heterogeneity, promotes long-term coexistence of two pathogen types in simulations of a population model. This tradeoff introduces an alternative strategy for the pathogen: a low-transmission, low-variability type can coexist with the high-transmission type favoured by classical non-heterogeneity models. In addi- tion, this tradeoff can help explain the extensive phenotypic variation we observed in field-col- lected pathogen isolates, in traits affecting virus fitness including transmission and environmental persistence. Similar heterogeneity tradeoffs might be a general mechanism promoting phenotypic variation in any pathogen for which hosts vary continuously in susceptibility.hosts vary continuously in susceptibility.)

• Effects of host heterogeneity on pathogen diversity and evolution  +