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Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature

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Category
General Reference
author-supplied keywords
keywords
authors
Mauricio Cruz-Loya
Tina Manzhu Kang
Natalie Ann Lozano
Rina Watanabe
Elif Tekin
Robert Damoiseaux
Van M. Savage
Pamela J. Yeh
title
Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature
type
newspaper_article
year
2018
source
ISME Journal
pages
12-23
volume
13
issue
1
publisher
Nature Publishing Group
link
https://www.mendeley.com/catalogue/d3d8fcd4-426f-3146-8d93-fcb12e70069c/(Error!"Error!" is not a number.)

Abstract

Environmental factors like temperature, pressure, and pH partly shaped the evolution of life. As life progressed, new stressors (e.g., poisons and antibiotics) arose as part of an arms race among organisms. Here we ask if cells co-opted existing mechanisms to respond to new stressors, or whether new responses evolved de novo. We use a network-clustering approach based purely on phenotypic growth measurements and interactions among the effects of stressors on population growth. We apply this method to two types of stressors—temperature and antibiotics—to discover the extent to which their cellular responses overlap in Escherichia coli. Our clustering reveals that responses to low and high temperatures are clearly separated, and each is grouped with responses to antibiotics that have similar effects to cold or heat, respectively. As further support, we use a library of transcriptional fluorescent reporters to confirm heat-shock and cold-shock genes are induced by antibiotics. We also show strains evolved at high temperatures are more sensitive to antibiotics that mimic the effects of cold. Taken together, our results strongly suggest that temperature stress responses have been co-opted to deal with antibiotic stress.

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15
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Identifiers

  • doi: 10.1038/s41396-018-0241-7 (Google search)
  • issn: 17517370
  • sgr: 85053304219
  • pmid: 30171253
  • scopus: 2-s2.0-85053304219
  • pui: 623909493

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