Santa Fe Institute Collaboration Platform

COMPLEX TIME: Adaptation, Aging, & Arrow of Time

Get Involved!
Contact: Caitlin Lorraine McShea, Program Manager, cmcshea@santafe.edu

Structure, function and diversity of the healthy human microbiome

From Complex Time
Revision as of 04:44, January 31, 2019 by RobertMarsland (talk | contribs) (Created page with "{{Reference Material |Meeting=Irreversible Processes in Ecological Evolution |Added by=RobertMarsland |title=Structure, function and diversity of the healthy human microbiome...")

(diff) ← Older revision | Approved revision (diff) | Latest revision (diff) | Newer revision → (diff)
Category
General Reference
author-supplied keywords
keywords
authors
Curtis Huttenhower
Dirk Gevers
Rob Knight
Sahar Abubucker
Jonathan H. Badger
Asif T. Chinwalla
Heather H. Creasy
Ashlee M. Earl
Michael G. Fitzgerald
Robert S. Fulton
Michelle G. Giglio
Kymberlie Hallsworth-Pepin
Elizabeth A. Lobos
Ramana Madupu
Vincent Magrini
John C. Martin
Makedonka Mitreva
Donna M. Muzny
Erica J. Sodergren
James Versalovic
Aye M. Wollam
Kim C. Worley
Jennifer R. Wortman
Sarah K. Young
Qiandong Zeng
Kjersti M. Aagaard
Olukemi O. Abolude
Emma Allen-Vercoe
Eric J. Alm
Lucia Alvarado
Gary L. Andersen
Scott Anderson
Elizabeth Appelbaum
Harindra M. Arachchi
Gary Armitage
Cesar A. Arze
Tulin Ayvaz
Carl C. Baker
Lisa Begg
Tsegahiwot Belachew
Veena Bhonagiri
Monika Bihan
Martin J. Blaser
Toby Bloom
Vivien Bonazzi
J. Paul Brooks
Gregory A. Buck
Christian J. Buhay
Dana A. Busam
Joseph L. Campbell
Shane R. Canon
Brandi L. Cantarel
Patrick S.G. Chain
I. Min A. Chen
Lei Chen
Shaila Chhibba
Ken Chu
Dawn M. Ciulla
Jose C. Clemente
Sandra W. Clifton
Sean Conlan
Jonathan Crabtree
Mary A. Cutting
Noam J. Davidovics
Catherine C. Davis
Todd Z. Desantis
Carolyn Deal
Kimberley D. Delehaunty
Floyd E. Dewhirst
Elena Deych
Yan Ding
David J. Dooling
Shannon P. Dugan
Wm Michael Dunne
A. Scott Durkin
Robert C. Edgar
Rachel L. Erlich
Candace N. Farmer
Ruth M. Farrell
Karoline Faust
Michael Feldgarden
Victor M. Felix
Sheila Fisher
Anthony A. Fodor
Larry J. Forney
Leslie Foster
Valentina Di Francesco
Jonathan Friedman
Dennis C. Friedrich
Catrina C. Fronick
Lucinda L. Fulton
Hongyu Gao
Nathalia Garcia
Georgia Giannoukos
Christina Giblin
Maria Y. Giovanni
Jonathan M. Goldberg
Johannes Goll
Antonio Gonzalez
Allison Griggs
Sharvari Gujja
Susan Kinder Haake
Brian J. Haas
Holli A. Hamilton
Emily L. Harris
Theresa A. Hepburn
Brandi Herter
Diane E. Hoffmann
Michael E. Holder
Clinton Howarth
Katherine H. Huang
Susan M. Huse
Jacques Izard
Janet K. Jansson
Huaiyang Jiang
Catherine Jordan
Vandita Joshi
James A. Katancik
Wendy A. Keitel
Scott T. Kelley
Cristyn Kells
Nicholas B. King
Dan Knights
Heidi H. Kong
Omry Koren
Sergey Koren
Karthik C. Kota
Christie L. Kovar
Nikos C. Kyrpides
Patricio S. La Rosa
Sandra L. Lee
Katherine P. Lemon
Niall Lennon
Cecil M. Lewis
Lora Lewis
Ruth E. Ley
Kelvin Li
Konstantinos Liolios
Bo Liu
Yue Liu
Chien Chi Lo
Catherine A. Lozupone
R. Dwayne Lunsford
Tessa Madden
Anup A. Mahurkar
Peter J. Mannon
Elaine R. Mardis
Victor M. Markowitz
Konstantinos Mavromatis
Jamison M. McCorrison
Daniel McDonald
Jean McEwen
Amy L. McGuire
Pamela McInnes
Teena Mehta
Kathie A. Mihindukulasuriya
Jason R. Miller
Patrick J. Minx
Irene Newsham
Chad Nusbaum
Michelle Oglaughlin
Joshua Orvis
Ioanna Pagani
Krishna Palaniappan
Shital M. Patel
Matthew Pearson
Jane Peterson
Mircea Podar
Craig Pohl
Katherine S. Pollard
Mihai Pop
Margaret E. Priest
Lita M. Proctor
Xiang Qin
Jeroen Raes
Jacques Ravel
Jeffrey G. Reid
Mina Rho
Rosamond Rhodes
Kevin P. Riehle
Maria C. Rivera
Beltran Rodriguez-Mueller
Yu Hui Rogers
Matthew C. Ross
Carsten Russ
Ravi K. Sanka
Pamela Sankar
J. Fah Sathirapongsasuti
Jeffery A. Schloss
Patrick D. Schloss
Thomas M. Schmidt
Matthew Scholz
Lynn Schriml
Alyxandria M. Schubert
Nicola Segata
Julia A. Segre
William D. Shannon
Richard R. Sharp
Thomas J. Sharpton
Narmada Shenoy
Nihar U. Sheth
Gina A. Simone
Indresh Singh
Christopher S. Smillie
Jack D. Sobel
Daniel D. Sommer
Paul Spicer
Granger G. Sutton
Sean M. Sykes
Diana G. Tabbaa
Mathangi Thiagarajan
Chad M. Tomlinson
Manolito Torralba
Todd J. Treangen
Rebecca M. Truty
Tatiana A. Vishnivetskaya
Jason Walker
Lu Wang
Zhengyuan Wang
Doyle V. Ward
Wesley Warren
Mark A. Watson
Christopher Wellington
Kris A. Wetterstrand
James R. White
Katarzyna Wilczek-Boney
Yuanqing Wu
Kristine M. Wylie
Todd Wylie
Chandri Yandava
Liang Ye
Yuzhen Ye
Shibu Yooseph
Bonnie P. Youmans
Lan Zhang
Yanjiao Zhou
Yiming Zhu
Laurie Zoloth
Jeremy D. Zucker
Bruce W. Birren
Richard A. Gibbs
Sarah K. Highlander
Barbara A. Methé
Karen E. Nelson
Joseph F. Petrosino
George M. Weinstock
Richard K. Wilson
Owen White
title
Structure, function and diversity of the healthy human microbiome
type
journal
year
2012
source
Nature
pages
207-214
volume
486
issue
7402
link
https://www.mendeley.com/catalogue/38346879-8379-367f-9b3d-a4de91eee5db/(2)

Abstract

Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin, and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics, and early microbial exposure have all been implicated. Accordingly, to characterize the ecology of human-associated microbial communities, the Human Microbiome Project has analyzed the largest cohort and set of distinct, clinically relevant body habitats to date. We found the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals. The project encountered an estimated 81–99% of the genera, enzyme families, and community configurations occupied by the healthy Western microbiome. Metagenomic carriage of metabolic pathways was stable among individuals despite variation in community structure, and ethnic/racial background proved to be one of the strongest associationa of both pathways and microbes with clinical metadata. These results thus delineate the range of structural and functional configurations normal in the microbial communities of a healthy population, enabling future characterization of the epidemiology, ecology, and translational applications of the human microbiome.

Counts

Citation count From Scopus. Refreshed every 5 days.
7952
Page views
11

Identifiers

  • doi: 10.1038/nature11234 (Google search)
  • issn: 00280836
  • sgr: 84862276328
  • isbn: 1476-4687 (Electronic) 0028-0836 (Linking)
  • pmid: 22699609
  • arxiv: NIHMS150003
  • scopus: 2-s2.0-84862276328
  • pui: 365006094

Add a file