View source for The Utility of Fisher's Geometric Model in Evolutionary Genetics Phenotypic complexity: the number of statistically independent phenotypic traits an organism exposes to natural selection in a given environment

{{Reference Material
|Meeting=Hallmarks of Biological Failure
|Added by=OphelieRonce
|title=The Utility of Fisher's Geometric Model in Evolutionary Genetics Phenotypic complexity: the number of statistically independent phenotypic traits an organism exposes to natural selection in a given environment
|type=journal
|year=2014
|source name=Annu. Rev. Ecol. Evol. Syst
|doi=10.1146/annurev-ecolsys-120213-091846
|abstract=The accumulation of data on the genomic bases of adaptation has triggered renewed interest in theoretical models of adaptation. Among these models, Fisher's geometric model (FGM) has received a lot of attention over the past two decades. FGM is based on a continuous multidimensional phenotypic landscape, but it is mostly used for the emerging properties of individual mutation effects. Despite its apparent simplicity and limited number of pa-rameters, FGM integrates a full model of mutation and epistatic interactions that allows the study of both beneficial and deleterious mutations and, subse-quently, the fate of evolving populations. In this review, I present the different properties of FGM and the qualitative and quantitative support they have received from experimental evolution data. I then discuss how to estimate the different parameters of the model and outline some future directions to connect FGM and the molecular determinants of adaptation.
|Mendeley link=http://www.mendeley.com/research/utility-fishers-geometric-model-evolutionary-genetics-phenotypic-complexity-number-statistically-ind
|pages=179-201
|volume=45
}}