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Does LC firing trigger upstate or is LC firing triggered by cortical down state?
Can paramaterizing models with anatomical distances and scaled time-constants lead to emergent behavior in dynamics of sleep wake cycles consistent with data?
What is the history dependence of sleep states? Are all REM and NREM sleep bouts created equal over the course of a night?
Oscillations: What sets the intrinsic rhythm of a cortical area? What reads out the phase-ordered temporal sequence of spikes?
Can animals have more localized forms of sleep?
How are the electrophysiological signals of REM sleep related to its functions?
How can animals with close phylogenetic relations show such different sleep patterns?
Do we have a phylogenetic history of the different functions/phenotypes of sleep?