What is Sleep?/ElizabethKlerman
From Complex Time
Notes by user Elizabeth Klerman (Harvard Medical School) for What is Sleep?
Post-meeting Reflection
1+ paragraphs on any combination of the following:
- Presentation highlights
- Open questions that came up
- How your perspective changed
- Impact on your own work
- e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group
- Have information/discussion about non-brain "functions" of sleep (e.g., metabolism, immune function) with their time scales
- Other brain "functions" of sleep to include are: mood/psychiatry; objective neurobehavioral performance;
- What are target/pivot points for changing some aspect of sleep?
Reference material notes
Some examples:
- Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
- Here is a free tool for calculating [ABC] (insert link)
- This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
- Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).
Reference Materials
Title | Author name | Source name | Year | Citation count From Scopus. Refreshed every 5 days. | Page views | Related file |
---|---|---|---|---|---|---|
Review: On mathematical modeling of circadian rhythms, performance, and alertness | Elizabeth B. Klerman, Melissa St Hilaire | Journal of Biological Rhythms | 2007 | 0 | 0 | |
A two process model of sleep regulation | A. A. Borbely | Human Neurobiology | 1982 | 0 | 3 | |
Mathematical model of the human circadian system with two interacting oscillators. | R. E. Kronauer, C. A. Czeisler, S. F. Pilato, M. C. Moore-Ede, E. D. Weitzman | The American journal of physiology | 1982 | 0 | 2 | |
Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans | S. H. Strogatz, R. E. Kronauer, C. A. Czeisler | Sleep | 1986 | 0 | 0 | |
Circadian pacemaker interferes with sleep onset at specific times each day: Role in insomnia | S. H. Strogatz, R. E. Kronauer, C. A. Czeisler | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 1987 | 0 | 0 | |
A quantitative model for the effects of light on the amplitude and phase of the deep circadian pacemaker based on human data | Richard E. Kronauer | 0 | 11 | |||
Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans | Derk Jan Dijk, Charles A. Czeisler | Neuroscience Letters | 1994 | 0 | 1 | |
Simulations of light effects on the human circadian pacemaker: Implications for assessment of intrinsic period | Elizabeth B. Klerman, Derk Jan Dijk, Richard E. Kronauer, Charles A. Czeisler | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 1996 | 0 | 0 | |
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms | Derk Jan Dijk, Jeanne F. Duffy, Eymard Kiel, Theresa L. Shanahan, Charles A. Czeisler | Journal of Physiology | 1999 | 0 | 0 | |
A Simpler Model of the Human Circadian Pacemaker | Daniel B. Forger, Megan E. Jewett, Richard E. Kronauer | Journal of Biological Rhythms | 1999 | 0 | 1 | |
Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range | Richard E. Kronauer, Megan E. Jewett, Daniel B. Forger | Journal of Biological Rhythms | 1999 | 0 | 1 | |
Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day | James K. Wyatt, Angela Ritz-De Cecco, Charles A. Czeisler, Derk Jan Dijk | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 1999 | 0 | 0 | |
Peak of circadian melatonin rhythm occurs later within the sleep of older subjects | Jeanne F. Duffy, Jamie M. Zeitzer, David W. Rimmer, Elizabeth B. Klerman, Derk Jan Dijk, Charles A. Czeisler | American Journal of Physiology - Endocrinology and Metabolism | 2002 | 0 | 1 | |
Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans | Kenneth P. Wright, Claude Gronfier, Jeanne F. Duffy, Charles A. Czeisler | Journal of Biological Rhythms | 2005 | 0 | 1 | |
An opposite role for tau in circadian rhythms revealed by mathematical modeling | Monica Gallego, Erik J. Eide, Margaret F. Woolf, David M. Virshup, Daniel B. Forger | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 0 | 0 | |
Macroscopic Models for Human Circadian Rhythms | 0 | 0 | ||||
Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker | Melissa A. St. Hilaire, Elizabeth B. Klerman, Sat Bir S. Khalsa, Kenneth P. Wright, Charles A. Czeisler, Richard E. Kronauer | Journal of Theoretical Biology | 2007 | 0 | 0 | |
Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans | Joshua J. Gooley, Kyle Chamberlain, Kurt A. Smith, Sat Bir S. Khalsa, Shantha M.W. Rajaratnam, Eliza Van Reen, Jamie M. Zeitzer, Charles A. Czeisler, Steven W. Lockley | Journal of Clinical Endocrinology and Metabolism | 2011 | 0 | 1 | |
Mammalian sleep dynamics: How diverse features arise from a common physiological framework | Andrew J.K. Phillips, Peter A. Robinson, David J. Kedziora, Romesh G. Abeysuriya | PLoS Computational Biology | 2010 | 0 | 0 | |
Timing of Sleep and Its Relationship with the Endogenous Melatonin Rhythm | Tracey L. Sletten, Simon Vincenzi, Jennifer R. Redman, Steven W. Lockley, Shantha M. W. Rajaratnam | Frontiers in Neurology | 2010 | 0 | 0 | |
Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology | Andrew J.K. Phillips, Charles A. Czeisler, Elizabeth B. Klerman | Journal of Biological Rhythms | 2011 | 0 | 0 | |
Entrainment of the human circadian clock to the natural light-dark cycle | Kenneth P. Wright, Andrew W. McHill, Brian R. Birks, Brandon R. Griffin, Thomas Rusterholz, Evan D. Chinoy | Current Biology | 2013 | 0 | 0 | |
Comparing the Morningness-Eveningness Questionnaire and Munich ChronoType Questionnaire to the dim light melatonin onset | Thomas Kantermann, Haein Sung, Helen J. Burgess | Journal of Biological Rhythms | 2015 | 0 | 4 | |
A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period | Min Zhou, Jae Kyoung Kim, Gracie Wee Ling Eng, Daniel B. Forger, David M. Virshup | Molecular Cell | 2015 | 0 | 0 | |
Are individual differences in sleep and circadian timing amplified by use of artificial light sources? | Krithika Swaminathan, Elizabeth B. Klerman, Andrew J.K. Phillips | Journal of Biological Rhythms | 2017 | 0 | 0 | |
Control of Mammalian Circadian Rhythm by CKI -Regulated Proteasome-Mediated PER2 Degradation | E. J. Eide, M. F. Woolf, H. Kang, P. Woolf, W. Hurst, F. Camacho, E. L. Vielhaber, A. Giovanni, D. M. Virshup | Molecular and Cellular Biology | 2005 | 0 | 1 | |
Genetics of the human circadian clock and sleep homeostat | Ashbrook, Krystal, Fu, Ptacek | 2019 | 0 | 2 | ||
Circadian phenotype impacts the brain's resting-state functional connectivity, attentional performance, and sleepiness | Elise R. Facer-Childs, Brunno M. Campos, Benita Middleton, Debra J. Skene, Andrew P. Bagshaw | Sleep | 2019 | 0 | 0 | |
An exploration of the temporal dynamics | Kronauer, St. Hilare, Rahman, Czeisler, Klerman | J Biol Rhythms | 2019 | 0 | 0 | |
High sensitivity and interindividual variability in the response of the human circadian system to evening light | Andrew J.K. Phillips, Parisa Vidafar, Angus C. Burns, Elise M. McGlashan, Clare Anderson, Shantha M.W. Rajaratnam, Steven W. Lockley, Sean W. Cain | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 0 | 2 |