What is Sleep?/ElizabethKlerman
From Complex Time
Notes by user Elizabeth Klerman (Harvard Medical School) for What is Sleep?
Post-meeting Reflection
1+ paragraphs on any combination of the following:
- Presentation highlights
- Open questions that came up
- How your perspective changed
- Impact on your own work
- e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group
- Add information/discussion about non-brain "functions" of sleep (e.g., metabolism, immune function) with their time scales
- Add Other brain "functions" of sleep to include are: mood/psychiatry; objective neurobehavioral performance; "cleaning" of toxic substances (glymphatics); neurochemistry
- What are target/pivot points for changing some aspect of sleep?
- How to define and then study sleep "need"? Is it different for each function? with age? How does it interact with sleep duration or timing of sleep?
Reference material notes
Some examples:
- Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
- Here is a free tool for calculating [ABC] (insert link)
- This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
- Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).
Reference Materials
Title | Author name | Source name | Year | Citation count From Scopus. Refreshed every 5 days. | Page views | Related file |
---|---|---|---|---|---|---|
Review: On mathematical modeling of circadian rhythms, performance, and alertness | Elizabeth B. Klerman, Melissa St Hilaire | Journal of Biological Rhythms | 2007 | 0 | 0 | |
A two process model of sleep regulation | A. A. Borbely | Human Neurobiology | 1982 | 0 | 3 | |
Mathematical model of the human circadian system with two interacting oscillators. | R. E. Kronauer, C. A. Czeisler, S. F. Pilato, M. C. Moore-Ede, E. D. Weitzman | The American journal of physiology | 1982 | 0 | 2 | |
Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans | S. H. Strogatz, R. E. Kronauer, C. A. Czeisler | Sleep | 1986 | 0 | 0 | |
Circadian pacemaker interferes with sleep onset at specific times each day: Role in insomnia | S. H. Strogatz, R. E. Kronauer, C. A. Czeisler | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 1987 | 0 | 0 | |
A quantitative model for the effects of light on the amplitude and phase of the deep circadian pacemaker based on human data | Richard E. Kronauer | 0 | 11 | |||
Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans | Derk Jan Dijk, Charles A. Czeisler | Neuroscience Letters | 1994 | 0 | 1 | |
Simulations of light effects on the human circadian pacemaker: Implications for assessment of intrinsic period | Elizabeth B. Klerman, Derk Jan Dijk, Richard E. Kronauer, Charles A. Czeisler | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 1996 | 0 | 0 | |
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms | Derk Jan Dijk, Jeanne F. Duffy, Eymard Kiel, Theresa L. Shanahan, Charles A. Czeisler | Journal of Physiology | 1999 | 0 | 0 | |
A Simpler Model of the Human Circadian Pacemaker | Daniel B. Forger, Megan E. Jewett, Richard E. Kronauer | Journal of Biological Rhythms | 1999 | 0 | 1 | |
Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range | Richard E. Kronauer, Megan E. Jewett, Daniel B. Forger | Journal of Biological Rhythms | 1999 | 0 | 1 | |
Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day | James K. Wyatt, Angela Ritz-De Cecco, Charles A. Czeisler, Derk Jan Dijk | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 1999 | 0 | 0 | |
Peak of circadian melatonin rhythm occurs later within the sleep of older subjects | Jeanne F. Duffy, Jamie M. Zeitzer, David W. Rimmer, Elizabeth B. Klerman, Derk Jan Dijk, Charles A. Czeisler | American Journal of Physiology - Endocrinology and Metabolism | 2002 | 0 | 1 | |
Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans | Kenneth P. Wright, Claude Gronfier, Jeanne F. Duffy, Charles A. Czeisler | Journal of Biological Rhythms | 2005 | 0 | 1 | |
An opposite role for tau in circadian rhythms revealed by mathematical modeling | Monica Gallego, Erik J. Eide, Margaret F. Woolf, David M. Virshup, Daniel B. Forger | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 0 | 0 | |
Macroscopic Models for Human Circadian Rhythms | 0 | 0 | ||||
Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker | Melissa A. St. Hilaire, Elizabeth B. Klerman, Sat Bir S. Khalsa, Kenneth P. Wright, Charles A. Czeisler, Richard E. Kronauer | Journal of Theoretical Biology | 2007 | 0 | 0 | |
Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans | Joshua J. Gooley, Kyle Chamberlain, Kurt A. Smith, Sat Bir S. Khalsa, Shantha M.W. Rajaratnam, Eliza Van Reen, Jamie M. Zeitzer, Charles A. Czeisler, Steven W. Lockley | Journal of Clinical Endocrinology and Metabolism | 2011 | 0 | 1 | |
Mammalian sleep dynamics: How diverse features arise from a common physiological framework | Andrew J.K. Phillips, Peter A. Robinson, David J. Kedziora, Romesh G. Abeysuriya | PLoS Computational Biology | 2010 | 0 | 0 | |
Timing of Sleep and Its Relationship with the Endogenous Melatonin Rhythm | Tracey L. Sletten, Simon Vincenzi, Jennifer R. Redman, Steven W. Lockley, Shantha M. W. Rajaratnam | Frontiers in Neurology | 2010 | 0 | 0 | |
Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology | Andrew J.K. Phillips, Charles A. Czeisler, Elizabeth B. Klerman | Journal of Biological Rhythms | 2011 | 0 | 0 | |
Entrainment of the human circadian clock to the natural light-dark cycle | Kenneth P. Wright, Andrew W. McHill, Brian R. Birks, Brandon R. Griffin, Thomas Rusterholz, Evan D. Chinoy | Current Biology | 2013 | 0 | 0 | |
Comparing the Morningness-Eveningness Questionnaire and Munich ChronoType Questionnaire to the dim light melatonin onset | Thomas Kantermann, Haein Sung, Helen J. Burgess | Journal of Biological Rhythms | 2015 | 0 | 4 | |
A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period | Min Zhou, Jae Kyoung Kim, Gracie Wee Ling Eng, Daniel B. Forger, David M. Virshup | Molecular Cell | 2015 | 0 | 0 | |
Are individual differences in sleep and circadian timing amplified by use of artificial light sources? | Krithika Swaminathan, Elizabeth B. Klerman, Andrew J.K. Phillips | Journal of Biological Rhythms | 2017 | 0 | 0 | |
Control of Mammalian Circadian Rhythm by CKI -Regulated Proteasome-Mediated PER2 Degradation | E. J. Eide, M. F. Woolf, H. Kang, P. Woolf, W. Hurst, F. Camacho, E. L. Vielhaber, A. Giovanni, D. M. Virshup | Molecular and Cellular Biology | 2005 | 0 | 1 | |
Genetics of the human circadian clock and sleep homeostat | Ashbrook, Krystal, Fu, Ptacek | 2019 | 0 | 2 | ||
Circadian phenotype impacts the brain's resting-state functional connectivity, attentional performance, and sleepiness | Elise R. Facer-Childs, Brunno M. Campos, Benita Middleton, Debra J. Skene, Andrew P. Bagshaw | Sleep | 2019 | 0 | 0 | |
An exploration of the temporal dynamics | Kronauer, St. Hilare, Rahman, Czeisler, Klerman | J Biol Rhythms | 2019 | 0 | 0 | |
High sensitivity and interindividual variability in the response of the human circadian system to evening light | Andrew J.K. Phillips, Parisa Vidafar, Angus C. Burns, Elise M. McGlashan, Clare Anderson, Shantha M.W. Rajaratnam, Steven W. Lockley, Sean W. Cain | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 0 | 2 |