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Difference between revisions of "What is Sleep?/GinaPoe"

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|Post-meeting summary=I like starting our meeting “What is sleep?” with a session on function, because sleep looks different in different animals. so to figure out what sleep is we need to figure out what it does, then figure out what is necessary (conditions) to do that function then look for those conditions across ages and species.
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Of course we have to start with some fundamentals and commonalities of sleep, even though we don’t know if they do - or should - define sleep or whether it is incidental-- a side effect, instead of an essential to sleep. I believe that thanks in part to the people here today, we have that starting point. We also have some basic functions of sleep identified, although it has been messy because until recently we have not known enough about those functions to adequately test whether sleep is important to those functions. But, again, we are at the point where we we have enough clues to start our reverse engineering phase.
 +
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In those early days we could not reverse engineer because we haven’t known what brain areas were responsible for what kind of learning and what neurotransmitters and electrical activity signatures were needed. But now, thanks to a horde of thousands, we know a few essential things:
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Theta, gamma,
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ACh, NE/DA
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 +
Phosphorylation
 +
 +
Potentiation/depotentiation, engrams, ARC, cFos, mRNA, protein synthesis,
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Circuits: what is interconnected. How specifically NE and ACh targets forebrain,
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 +
Order of play: cortical registration, Hippocampcampal assembly, and eventual cortical strengthening...
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 +
Now we are ready to roll up our sleeves and figure out what sleep really is!
 
|Reference material notes=Here is an excellent paper clearly spelling out all the hypotheses related to sleep for learning and forgetting (besides Susan and my J Neurosci 2019 articles!) - Jesse J. Langille, Remembering to forget: A dual role for sleep oscillations in memory consolidation and forgetting. Frontiers in Cellular Neuroscience 13:1, 2019. dob: 10.3389/fncel.2019.00071
 
|Reference material notes=Here is an excellent paper clearly spelling out all the hypotheses related to sleep for learning and forgetting (besides Susan and my J Neurosci 2019 articles!) - Jesse J. Langille, Remembering to forget: A dual role for sleep oscillations in memory consolidation and forgetting. Frontiers in Cellular Neuroscience 13:1, 2019. dob: 10.3389/fncel.2019.00071
 
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Revision as of 10:59, November 18, 2019

Notes by user Gina Poe (UCLA) for What is Sleep?

Post-meeting Reflection

1+ paragraphs on any combination of the following:

  • Presentation highlights
  • Open questions that came up
  • How your perspective changed
  • Impact on your own work
  • e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

I like starting our meeting “What is sleep?” with a session on function, because sleep looks different in different animals. so to figure out what sleep is we need to figure out what it does, then figure out what is necessary (conditions) to do that function then look for those conditions across ages and species.

Of course we have to start with some fundamentals and commonalities of sleep, even though we don’t know if they do - or should - define sleep or whether it is incidental-- a side effect, instead of an essential to sleep. I believe that thanks in part to the people here today, we have that starting point. We also have some basic functions of sleep identified, although it has been messy because until recently we have not known enough about those functions to adequately test whether sleep is important to those functions. But, again, we are at the point where we we have enough clues to start our reverse engineering phase.

In those early days we could not reverse engineer because we haven’t known what brain areas were responsible for what kind of learning and what neurotransmitters and electrical activity signatures were needed. But now, thanks to a horde of thousands, we know a few essential things:

Theta, gamma,

ACh, NE/DA

Phosphorylation

Potentiation/depotentiation, engrams, ARC, cFos, mRNA, protein synthesis,

Circuits: what is interconnected. How specifically NE and ACh targets forebrain,

Order of play: cortical registration, Hippocampcampal assembly, and eventual cortical strengthening...

Now we are ready to roll up our sleeves and figure out what sleep really is!

Reference material notes

Some examples:

  • Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
  • Here is a free tool for calculating [ABC] (insert link)
  • This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
  • Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).

Here is an excellent paper clearly spelling out all the hypotheses related to sleep for learning and forgetting (besides Susan and my J Neurosci 2019 articles!) - Jesse J. Langille, Remembering to forget: A dual role for sleep oscillations in memory consolidation and forgetting. Frontiers in Cellular Neuroscience 13:1, 2019. dob: 10.3389/fncel.2019.00071

Reference Materials

Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
REM sleep selectively prunes and maintains new synapses in development and learning Wei Li, Lei Ma, Guang Yang, Wen Biao Gan Nature Neuroscience 2017 0 0
Experience-dependent phase-reversal of hippocampal neuron firing during REM sleep Gina R. Poe, Douglas A. Nitz, Bruce L. McNaughton, Carol A. Barnes Brain Research 2000 0 0
Antidepressant suppression of non-REM sleep spindles and REM sleep impairs hippocampus-dependent learning while augmenting striatum-dependent learning Alain Watts, Howard J. Gritton, Jamie Sweigart, Gina R. Poe Journal of Neuroscience 2012 0 0
Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory consolidation Victoria Booth, Gina R. Poe Hippocampus 2006 0 0
Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory Kevin M. Swift, Brooks A. Gross, Michelle A. Frazer, David S. Bauer, Kyle J.D. Clark, Elena M. Vazey, Gary Aston-Jones, Yong Li, Anthony E. Pickering, Susan J. Sara, Gina R. Poe Current Biology 2018 0 0
Remembering to forget: A dual role for sleep oscillations in memory consolidation and forgetting Jesse J. Langille Frontiers in Cellular Neuroscience 2019 0 0
REM restriction persistently alters strategy used to solve a spatial task Theresa E. Bjorness, Brett T. Riley, Michael K. Tysor, Gina R. Poe Learning and Memory 2005 0 0
Sleep contributes to dendritic spine formation and elimination in the developing mouse somatosensory cortex Guang Yang, Wen Biao Gan Developmental Neurobiology 2012 0 0
Sleep is for forgetting Gina R. Poe Journal of Neuroscience 2017 0 0
The human emotional brain without sleep - a prefrontal amygdala disconnect Seung Schik Yoo, Ninad Gujar, Peter Hu, Ferenc A. Jolesz, Matthew P. Walker Current Biology 2007 0 0
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep Graham H. Diering, Raja S. Nirujogi, Richard H. Roth, Paul F. Worley, Akhilesh Pandey, Richard L. Huganir Science 2017 0 0
The function of dream sleep Francis Crick, Graeme Mitchison Nature 1983 0 0
Cognitive neuroscience of sleep Gina R. Poe, Christine M. Walsh, Theresa E. Bjorness Progress in Brain Research 2010 0 0

Presenter on the following Agenda items

Is sleep for remembering or forgetting?

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