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| − | {{Meeting
| + | <gdoc id="1OTIH7Sm0oL0_tDa2IiK-wH6om5AEfgsWZ8T6gcZaGZ0" /> |
| − | |Start date/time=November 13, 2019
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| − | |End date/time=November 15, 2019
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| − | |Organizers=DavidBaum;OanaCarja;ChrisKempes
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| − | |Meeting summary=The goal of this working group is to address the onset of adaptive evolution in a prebiotic context. What theories or models of evolution allow selection-like processes to begin prior to genetic inheritance systems, and what spatial contexts do these models require (from well-mixed systems, to 2D-arrays, to protocells)? We will discuss existing theories, as well as needed evolutionary frameworks to understand how chemical systems became biological systems. Can we use evolutionary theory to guide the design of experiments aimed at understanding how systems become capable of making the transition from the abiotic to biotic?
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| − | |Additional info=For this meeting, we would like everyone to consider the following list of questions:
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| − | # What theories or models of evolution allow selection-like processes to begin prior to genetic inheritance systems? What spatial contexts do these models require (from well-mixed systems, to 2D-arrays, to protocells, to systems with different rates of diffusion for different classes of molecule)? How important is spatial structure within this context?
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| − | # If life starts with non-genetic modes of heritability (e.g., compositional), when, how and why might genetic encoding systems invade?
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| − | # What are missing components of current evolutionary theory and experimental design for realizing systems that can make the transition from chemistry to biology?
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| − | # When do changes in the dynamical state of a chemical system constitute analogs of development/succession, and when of evolution?
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| − | # Origin of life theory often invokes “autocatalysis,” but there are many kinds invoked (e.g., RNA-complement templating; hypercycles; RAF sets; branched-networks like the rTCA). What kind(s) of autocatalytic mechanisms are easiest to imagine arising spontaneously? What kind(s) are most amenable to evolving towards life-like complexity?
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| − | |Attendee list=CeliaBlanco;MarkDitzler;EmilyDolson;StevenFrank;BenKerr;SamuelLevine;OmerMarkovitch;WillRatcliffe;SaraWalker
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