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- User:AaronGoldman + (The Goldman lab studies protein and proteo … The Goldman lab studies protein and proteome evolution with a special focus on early cellular life and the emergence of ancient metabolic systems. The evolutionary tree of life coalesces into a single root representing an ancestral population that lived about 3.5 billion years ago. Many features of these ancestors are still buried within the genomes of organisms alive today. Evolution over billions of years has obscured the ancient signature of most of these features, making them difficult to identify.</br></br>Our lab takes advantage of the tremendous growth in genomic and proteomic data to find these ancient genes and reassemble them into metabolic and physiological systems. Much of this work begins with our database, which brings multiple independent lines of evidence together into a single framework. We develop complex algorithms and use a range of computational biology methods to identify ancient genes and test hypotheses about early evolutionary history.potheses about early evolutionary history.)