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Cognitive Regime Shift II - When/why/how the Brain Breaks/DietmarPlenz

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Notes by user Dietmar Plenz (NIH) for Cognitive Regime Shift II - When/why/how the Brain Breaks

Post-meeting Reflection

1+ paragraphs on any combination of the following:

  • Presentation highlights
  • Open questions that came up
  • How your perspective changed
  • Impact on your own work
  • e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

HIghlights:

Hard to prioritize as every talk expanded my perspective and triggered new associations.

I enjoyed two talks in particular – David’s introduction into ‘breaking’ which provided are nice meta-overview into brain dysfunction outside the usual context of development and aging. Refreshing and lots of food for thoughts.  The triade of ‘breaking/perturbation, critical transition, and cascading failure’ nice transitioned into three more concrete directions, which I would loved to have explored more in that workshop:

‘breaking = scale of anatomy’

‘critical transition = brain state’

‘cascading failure = developmental disturbances’?

Also very much enjoyed Nikolaus’s overview talk and insight into convolutional deep networks.  Very clear, transparent and a great platform from which discussions emerged.

My favorite open question:

What is the computation mechanism/dynamics at the network level ? Move away from correlation analyses.

Change in perspective: I would like to move away from the discussion of imaging results and move more towards the nature of computation.

Impact on my own work: Converging ideas on collective decision making and coherence potentials.

Reference material notes

Some examples:

  • Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
  • Here is a free tool for calculating [ABC] (insert link)
  • This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
  • Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).
  • Meisel et al. 2017 demonstrates that sleep deprivation associated with rapid cognitive decline correlates with a deviation from critical dynamics quantified in the change in long-term temporal correlations or critical slowing down.
  • Seshadri et al. 2018: using an animal model for schizophrenia, it is shown that a hallmark of the disease – loss of working memory – correlates with deviation from avalanche dynamics. Memory performance and critical dynamics can be acutely rescued with the NMDA receptor agonist D-serine.

Reference Materials

Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
Decline of long-range temporal correlations in the human brain during sustained wakefulness Christian Meisel, Kimberlyn Bailey, Peter Achermann, Dietmar Plenz Scientific Reports 2017 0 3 Download
Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment Saurav Seshadri, Andreas Klaus, Daniel E. Winkowski, Patrick O. Kanold, Dietmar Plenz Translational Psychiatry 2018 0 4 Download
Neuronal avalanches and coherence potentials D. Plenz European Physical Journal: Special Topics 2012 0 1 Download (Encrypted)
Coherence potentials: Loss-less, all-or-none network events in the cortex Tara C. Thiagarajan, Mikhail A. Lebedev, Miguel A. Nicolelis, Dietmar Plenz PLoS Biology 2010 0 1 Download (Encrypted)