Cognitive Regime Shift II - When/why/how the Brain Breaks/DietmarPlenz
Notes by user Dietmar Plenz (NIH) for Cognitive Regime Shift II - When/why/how the Brain Breaks
Post-meeting Reflection
1+ paragraphs on any combination of the following:
- Presentation highlights
- Open questions that came up
- How your perspective changed
- Impact on your own work
- e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group
HIghlights:
Hard to prioritize as every talk expanded my perspective and triggered new associations.
I enjoyed two talks in particular – David’s introduction into ‘breaking’ which provided are nice meta-overview into brain dysfunction outside the usual context of development and aging. Refreshing and lots of food for thoughts. The triade of ‘breaking/perturbation, critical transition, and cascading failure’ nice transitioned into three more concrete directions, which I would loved to have explored more in that workshop:
‘breaking = scale of anatomy’
‘critical transition = brain state’
‘cascading failure = developmental disturbances’?
Also very much enjoyed Nikolaus’s overview talk and insight into convolutional deep networks. Very clear, transparent and a great platform from which discussions emerged.
My favorite open question:
What is the computation mechanism/dynamics at the network level ? Move away from correlation analyses.
Change in perspective: I would like to move away from the discussion of imaging results and move more towards the nature of computation.
Impact on my own work: Converging ideas on collective decision making and coherence potentials.
Reference material notes
Some examples:
- Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
- Here is a free tool for calculating [ABC] (insert link)
- This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
- Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).
- Meisel et al. 2017 demonstrates that sleep deprivation associated with rapid cognitive decline correlates with a deviation from critical dynamics quantified in the change in long-term temporal correlations or critical slowing down.
- Seshadri et al. 2018: using an animal model for schizophrenia, it is shown that a hallmark of the disease – loss of working memory – correlates with deviation from avalanche dynamics. Memory performance and critical dynamics can be acutely rescued with the NMDA receptor agonist D-serine.
Reference Materials
| Title | Author name | Source name | Year | Citation count From Scopus. Refreshed every 5 days. | Page views | Related file |
|---|---|---|---|---|---|---|
| Decline of long-range temporal correlations in the human brain during sustained wakefulness | Christian Meisel, Kimberlyn Bailey, Peter Achermann, Dietmar Plenz | Scientific Reports | 2017 | 0 | 3 | Download |
| Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment | Saurav Seshadri, Andreas Klaus, Daniel E. Winkowski, Patrick O. Kanold, Dietmar Plenz | Translational Psychiatry | 2018 | 0 | 4 | Download |
| Neuronal avalanches and coherence potentials | D. Plenz | European Physical Journal: Special Topics | 2012 | 0 | 1 | Download (Encrypted) |
| Coherence potentials: Loss-less, all-or-none network events in the cortex | Tara C. Thiagarajan, Mikhail A. Lebedev, Miguel A. Nicolelis, Dietmar Plenz | PLoS Biology | 2010 | 0 | 1 | Download (Encrypted) |
