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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Cognitive Regime Shift II - When/why/how the Brain Breaks/PaulGarcia

From Complex Time

Notes by user Paul Garcia (Columbia University) for Cognitive Regime Shift II - When/why/how the Brain Breaks

Post-meeting Reflection

1+ paragraphs on any combination of the following:

  • Presentation highlights
  • Open questions that came up
  • How your perspective changed
  • Impact on your own work
  • e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

Brains fail - like bridges, like suspenders, and like relationships. The brain constantly operates at a point of criticality - at least for our optimal cognitive state. Adaptive systems with connectivity often have cascading failures. Can the brain heal itself? Is this robustness? Can that self-organization go wrong, or be improperly applied? It's not a bug - it's a feature. I am reminded of the "swiss-cheese model" familiar in root cause analysis. Multiple failures must be serially associated

Why do we care about a diagnosis? What is meant by a "proper" diagnosis? Does "diagnosis" imply stationarity. Must we have a tight mechanism to have a diagnosis? Or perhaps simply a cluster of symptoms. Or a basis in which to guide therapy I approach my patients based on what is the next thing I am going to do. Sledgehammer solutions. - may be best. Borrowing from vaccines, can we look at treatments as "learning". Pain is an example for a top-down approach to disease. Much like traditional Chinese medicine.

Highlight 1

Richard's buzzing that described experimental determination of the boson and how it related to inconsistencies in Alzheimer's Disease was simultaneously the most confusing and the most entertaining part of the conference.

Reference material notes

Some examples:

  • Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
  • Here is a free tool for calculating [ABC] (insert link)
  • This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
  • Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).
  • Wittmann M. 2015 is a good review on modulators of time perception.
  • The Morandi et al. 2017 outlines a common clinical scenario (acute brain failure) complicating medical care in aging patients.
  • Hasenkamp and Barsalou 2012 article puts a systems neuroscience framework over volitional control of focusing attention.

Reference Materials

Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
Modulations of the experience of self and time Marc Wittmann Consciousness and Cognition 2015 0 4 Download
The Diagnosis of Delirium Superimposed on Dementia: An Emerging Challenge Alessandro Morandi, Daniel Davis, Giuseppe Bellelli, Rakesh C. Arora, Gideon A. Caplan, Barbara Kamholz, Ann Kolanowski, Donna Marie Fick, Stefan Kreisel, Alasdair MacLullich, David Meagher, Karen Neufeld, Pratik P. Pandharipande, Sarah Richardson, Arjen J.C. Slooter, John P. Taylor, Christine Thomas, Zoë Tieges, Andrew Teodorczuk, Philippe Voyer, James L. Rudolph Journal of the American Medical Directors Association 2017 0 5
Effects of Meditation Experience on Functional Connectivity of Distributed Brain Networks Wendy Hasenkamp, Lawrence W. Barsalou Frontiers in Human Neuroscience 2012 0 5 Download