Cognitive Regime Shift II - When/why/how the Brain Breaks/RichardFrackowiak

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Notes by user Richard Frackowiak (Ecole Polytechnique Federale de Lausanne) for Cognitive Regime Shift II - When/why/how the Brain Breaks

Post-meeting Reflection

1+ paragraphs on any combination of the following:

• Presentation highlights
• Open questions that came up
• How your perspective changed
• Impact on your own work
• e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

Presentation highlight was about AI techniques, didactic, informative and comprehensible - thanks Nikolaus Kriegskorte.

There was tension between model and data led approaches.

I had a relatively stable view of the methods by which functional and structural imaging mao to anatomy and local function in human brains. Those views were not shared, which meant a rethink is required. I remain unconvinced by what the resting state can inform us about mapping function and structure

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Reference material notes

Some examples:

• Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
• Here is a free tool for calculating [ABC] (insert link)
• This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
• Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).
• Translation in cognitive neuroscience remains beyond the horizon, brought no closer by claimed major advances in our understanding of the brain. Nachev et al., propose that adequate individualisation, needed for accurate diagnosis, requires models of far greater dimensionality than has been usual in the field. This necessity arises from the widely distributed causality of neural systems, a consequence of the fundamentally adaptive nature of their developmental and physiological mechanisms.   
• A proposal that, in the next quarter century, advances in “cartography” will result in progressively more accurate drafts of a data-led, multi-scale model of normal, abnormal and even adapting, whole human brain structure and function. These draft blueprints will result from analysis of large volumes of neuroscientific and clinical data, by an iterative process of reconstruction, modelling and simulation.

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Reference Materials

Title	Author name	Source name	Year	Citation count From Scopus. Refreshed every 5 days.	Page views	Related file
The future of human cerebral cartography: A novel approach	Richard Frackowiak, Henry Markram	Philosophical Transactions of the Royal Society B: Biological Sciences	2015	0	7	Download (Encrypted)
Lost in translation	Parashkev Nachev, Geraint Rees, Richard Frackowiak	F1000Research	2019	0	7	Download (Encrypted)

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