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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Dynamic Multi-System Resilience in Human Aging/MarcelGMOldeRikkert

From Complex Time

Notes by user Marcel G.M. Olde Rikkert (Radboud Univ.) for Dynamic Multi-System Resilience in Human Aging

Post-meeting Reflection

1+ paragraphs on any combination of the following:

  • Presentation highlights
  • Open questions that came up
  • How your perspective changed
  • Impact on your own work
  • e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

I was amazed by the alternative vision of Dervis Can Vural about damage accumulation and aging in random network perspective. Among others it again helped me realize that downstream targeted therapies in chronic age related diseases (which mostly are directed by mechanisms of aging) probably are not to be of great help. The connections of nodes higher upstream, still being damaged or producing damage will still end up in causing the disease related decline.

The presentation of Peter Hofmman showed an elegant 'simple model' of stochastic damage accumulation and repair. It opened the perspective of ramdoness in resilience mechanisms, when the redundancy of reserve function has depleted. The three trajectories of damage and death occurence are very interesting, and I look very much forward to the statistical analyses of these data, after repeated runs of these models.

The talk of Alfons Hoekstra, showed that the multiscale modeling is fit for supporting resilience research and so is fit for being part of the workshop (though he humbly stated that multiscale modeling might not be mature enough for this challenge). The examples Alfons showed in the time -space scaling diagrammes and the connecting interactions do inspire to connect and likewise model subsystems depending on one another and creating a meaningful representation of challenges for aging persons.

Ravi Varadhan and Chhandi Dutta gave an excellent overview of the research grants given in the field by the NIA, and the models already published, respectively. These are excellent sources of comparison for further work.

Second day, we had a very inspiring lecture of Ingrid vd Leemput. The theoretical and empirical reasoning and analyses of ecosystems can be of great help in studying resilience systems in aging man.

Heather Whitson followed up with a nice clinical example. But not only the patient but also the family and physicians make up a complex adaptive system. She also paved the way to stress tests of different kinds, which was completed later on nicely by Warren Ladiges on animal models. This connection added new insights and clearly showed that beside computational models, the animal models are very valuable.

Last but not least Porter Swetsell gave eye openers on population resilience based on his scholarly and personal experiences with pueblo population resilience over time. These all got intertwined in the group discussion, which also opened up new opportunities for collaboration.

The meeting so far showed emergence of many new options, and warrants, inspires aand invites for further interaction and collaboration.

Reference material notes

Some examples:

  • Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
  • Here is a free tool for calculating [ABC] (insert link)
  • This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
  • Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).

Reference Materials

Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
To adapt or not to adapt: consequences of declining adaptive homeostasis and proteases with age 0 4

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