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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Dynamic Multi-System Resilience in Human Aging/ReneMelis

From Complex Time

Notes by user Rene Melis (Radboud Univ.) for Dynamic Multi-System Resilience in Human Aging

Post-meeting Reflection

1+ paragraphs on any combination of the following:

  • Presentation highlights
  • Open questions that came up
  • How your perspective changed
  • Impact on your own work
  • e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

Overall, it became clear to me how much perspectives there are from which you can study the subject of resilience and how valuable and complementary each of these perspectives is. I have identified a number of axes along which we can organize each of these perspectives to create some structure:

- Axis 1: from Understanding resilience to Diagnosis and prediction of levels of resilience in individuals.

- Axis 2: from Systemic to Subsystemic resilience(s) (links to spatial scale) and from longitudinal, long term trends to Short-term dynamics (links to temporal scale)

- Axis 3: from (in silico) Modeling of theory to Empircal data collection and validation

- Axis 4: from Between individual to Within individual differences

From this I expect we can think of a number of initiatives we can take together:

- Developing a measurement tool box to capture in a standardized way data we need to empirical study systemic and subsystemic resilience in human aging. This toolbox should begin to identify which core (organ) systems and physiological processes are (based on theory) involved to emerge resilience from. Then we can identify the stimulus-response test, time-series to follow (to calculate multiscale entropy and DIORs from) and crucial outcomes/function to be studied for each of the core systems involved.

- Standardization of perturbation quantification

Reference material notes

Some examples:

  • Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
  • Here is a free tool for calculating [ABC] (insert link)
  • This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
  • Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).

Reference Materials

Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
The resilience framework as a strategy to combat stress-related disorders3 Raffael Kalisch, Dewleen G. Baker, Ulrike Basten, Marco P. Boks, George A. Bonanno, Eddie Brummelman, Andrea Chmitorz, Guillén Fernàndez, Christian J. Fiebach, Isaac Galatzer-Levy, Elbert Geuze, Sergiu Groppa, Isabella Helmreich, Talma Hendler, Erno J. Hermans, Tanja Jovanovic, Thomas Kubiak, Klaus Lieb, Beat Lutz, Marianne B. Müller, Ryan J. Murray, Caroline M. Nievergelt, Andreas Reif, Karin Roelofs, Bart P.F. Rutten, David Sander, Anita Schick, Oliver Tüscher, Ilse Van Diest, Anne Laura Van Harmelen, Ilya M. Veer, Eric Vermetten, Christiaan H. Vinkers, Tor D. Wager, Henrik Walter, Michèle Wessa, Michael Wibral, Birgit Kleim Nature Human Behaviour 2017 44 4
The resilience framework as a strategy to combat stress-related disorders2 Raffael Kalisch, Dewleen G. Baker, Ulrike Basten, Marco P. Boks, George A. Bonanno, Eddie Brummelman, Andrea Chmitorz, Guillén Fernàndez, Christian J. Fiebach, Isaac Galatzer-Levy, Elbert Geuze, Sergiu Groppa, Isabella Helmreich, Talma Hendler, Erno J. Hermans, Tanja Jovanovic, Thomas Kubiak, Klaus Lieb, Beat Lutz, Marianne B. Müller, Ryan J. Murray, Caroline M. Nievergelt, Andreas Reif, Karin Roelofs, Bart P.F. Rutten, David Sander, Anita Schick, Oliver Tüscher, Ilse Van Diest, Anne Laura Van Harmelen, Ilya M. Veer, Eric Vermetten, Christiaan H. Vinkers, Tor D. Wager, Henrik Walter, Michèle Wessa, Michael Wibral, Birgit Kleim Nature Human Behaviour 2017 44 2
The resilience framework as a strategy to combat stress-related disorders 0 2