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In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated symptoms, prolongs lifespan in progeroid mice, and improves tissue homeostasis in older

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authors
title
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated symptoms, prolongs lifespan in progeroid mice, and improves tissue homeostasis in older
type
journal
year
2016
source
Cell
pages
1719-1733
volume
167

Abstract

Graphical Abstract Highlights d Partial reprogramming erases cellular markers of aging in mouse and human cells d Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan d In vivo reprogramming improves regeneration in 12-month-old wild-type mice

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