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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Irreversible Processes in Ecological Evolution/Pathogen diversity and negative frequency-dependent selection: consequences for intervention

From Complex Time

January 29, 2019
10:00 am - 11:00 am


Pamela Martinez (Harvard)


Understanding how populations respond to selective pressures is an active area of research, of particular relevance for pathogens, which often adapt after the implementation of epidemic control strategies. Yet attempts to anticipate how and when these populations will evolve, are challenging. By looking at population diversity of rotavirus and Streptococcus pneumoniae, we have explored the impact of negative-frequency dependent selection, which tends to confer an advantage to the rare and a disadvantage to the common, in the response to intervention. Our results emphasize the resilience to control measures, and thus low vaccine effectiveness, in pathogens for which frequency-dependent selection is a key driving force.

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Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
Differential and enhanced response to climate forcing in diarrheal disease due to rotavirus across a megacity of the developing world Proceedings of the National Academy of Sciences 2016 0 0
Prediction of post-vaccine population structure of Streptococcus pneumoniae using accessory gene frequencies bioRxiv 2018 0 1
Frequency-dependent selection in vaccine-associated pneumococcal population dynamics Nature Ecology and Evolution 2017 0 0