Aging in Single-celled Organisms: from Bacteria to the Whole Tree of Life/Stochasticity, immortality, and mortality in E. coli
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Revision as of 17:59, February 10, 2020 by AmyPChen (talk | contribs) (Created page with "{{Agenda item |Start time=February 10, 2020 10:45:00 AM |End time=February 10, 2020 11:15:00 |Is presentation=No |Presenter=LinChao |Pre-meeting notes=Here we show that the b...")
February 10, 2020
10:45 am - 11:15 am
- Presenter
Lin Chao (UC San Diego)
- Abstract
Here we show that the bacterium Escherichia coli exhibits both lineage mortality and immortality. The outcome depends on a whether a balance is achieved between damage accumulation and the asymmetric allocation of damage from mother to daughters. At low damage rates, both old and new daughters, which are allocated respectively more and less damage, generated immortal lineages that achieved stable growth rate equilibria. At high rates, mortality ensued because while the new daughter lineage persisted, the old daughter lineage stopped dividing. The stoppage was found to result from an increase in the stochasticity of cell growth.
- Presentation file(s)
- Related files
