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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Cognitive Regime Shift I - When the Brain Breaks/"Prion dynamics and latency"

From Complex Time

July 23, 2018
1:30 pm - 2:20 pm


David Krakauer (SFI)


A large number of neurodegenerative diseases feature the accumulation of mis-folded proteins. These include prion diseases, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. In all of these cases several different scales of organization are associated with disease progression or onset to include genetic, epigenetic, neural circuits, brain modules, and behavior. How should we best integrate data from each of these levels and what models and theories allow us to span levels? I shall discuss a few dynamical models of polymerization, protein accumulation, and protein diffusion through neural connections, that provide insights into disease progression at a number of different time and space scales. An ongoing challenge is a criterion for fixing thresholds that define an observable cognitive regime shift.

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