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Demography of dietary restriction and death in Drosophila

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Category
General Reference
author-supplied keywords
keywords
authors
title
Demography of dietary restriction and death in Drosophila
type
journal
year
2003
source
Science
pages
1731-1733
volume
301
issue
5640

Abstract

Dietary restriction (DR) increases life-span in organisms from yeast to mammals, presumably by slowing the accumulation of aging-related damage. Here we show that in Drosophila, DR extends life-span entirely by reducing the short-term risk of death. Two days after the application of DR at any age for the first time, previously fully fed flies are no more likely to die than flies of the same age that have been subjected to long-term DR. DR of mammals may also reduce short-term risk of death, and hence DR instigated at any age could generate a full reversal of mortality.

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Identifiers

  • doi: 10.1126/science.1086016 (Google search)
  • issn: 00368075
  • sgr: 0141766912
  • scopus: 2-s2.0-0141766912
  • pui: 37174368

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