In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated symptoms, prolongs lifespan in progeroid mice, and improves tissue homeostasis in older
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- title
- In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated symptoms, prolongs lifespan in progeroid mice, and improves tissue homeostasis in older
- type
- journal
- year
- 2016
- source
- Cell
- pages
- 1719-1733
- volume
- 167
Abstract
Graphical Abstract Highlights d Partial reprogramming erases cellular markers of aging in mouse and human cells d Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan d In vivo reprogramming improves regeneration in 12-month-old wild-type mice
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Identifiers
- doi: 10.1016/j.cell.2016.11.052 (Google search)
