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- Robustness in biological and social systems + (Defined as the invariance of system struct … Defined as the invariance of system structure or function following a nontrivial perturbation to one or more important system components, robustness is a characteristic property of all adaptive systems. This chapter reviews the theory of robustness in biology, the design of experiments used to assay robustness (including the functional behavior or outputs of a system), and the adaptive response of those parts or components which are compromised by a perturbation. Emphasis is given to a rigorous logic of measurements that carefully factors apart the many casual contributions to robust function. Insights from the study of robustness in biology are applied to the social and decision-making domains, and modifications of experimental design and theory are proposed to account for challenges unique to human agents.unt for challenges unique to human agents.)