"%3AAbstract%2FAfrican-20Americans-20have-20double-20the-20prevalence-20of-20Alzheimer%E2%80%99s-20disease-20%28AD%29%2C-20as-20compared-20to-20European-20Americans.-20However%2C-20the-20underlying-20causes-20of-20this-20health-20disparity-20are-20due-20to-20a-20multitude-20of-20environmental%2C-20lifestyle%2C-20and-20genetic-20factors-20that-20are-20not-20yet-20fully-20understood.-20Here%2C-20we-20review-20the-20effects-20of-20the-20two-20largest-20genetic-20risk-20factors-20for-20AD-20in-20African-20Americans%3A-20Apolipoprotein-20E-20%28APOE%29-20and-20ABCA7.-20We-20will-20describe-20the-20direct-20effects-20of-20genetic-20variation-20on-20neural-20correlates-20of-20cognitive-20function-20and-20report-20the-20indirect-20modulating-20effects-20of-20genetic-20variation-20on-20modifiable-20AD-20risk-20factors%2C-20such-20as-20aerobic-20fitness.-20As-20a-20means-20of-20integrating-20previous-20findings%2C-20we-20present-20a-20novel-20schematic-20diagram-20to-20illustrate-20the-20many-20factors-20that-20contribute-20to-20AD-20risk-20and-20impaired-20cognitive-20function-20in-20older-20African-20Americans.-20Finally%2C-20we-20discuss-20areas-20that-20require-20further-20inquiry%2C-20and-20stress-20the-20importance-20of-20racially-20spanerse-20and-20representative-20study-20populations." contains a listed "%" character as part of the property label and has therefore been classified as invalid.

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