"%3AAbstract%2FAge-2Drelated-20alterations-20of-20the-20immune-20system-20affect-20both-20antibody-20and-20cell-2Dmediated-20immune-20responses%2C-20T-2Dcell-20responses-20being-20more-20severely-20affected-20than-20B-2Dcell-20responses.-20Within-20the-20T-2Dcell-20population%2C-20aging-20leads-20to-20replacement-20of-20virgin-20by-20memory-20cells-20and-20to-20accumulation-20of-20cells-20with-20signal-20transduction-20defects.-20Changes-20in-20T-2Dcell-20subsets-20and-20in-20cytokine-20production-20profiles-20may-20produce-20suitable-20conditions-20for-20T-2Dcell-2Dmediated-20disregulation-20of-20antibody-20responses-20characterized-20by-20the-20production-20of-20low-20affinity-20and-20self-2Dreactive-20antibodies.-20Also-20B-2Dcells-20exhibit-20intrinsic-20defects-20and-20natural-20killer-20%28NK%29-20cell-20activity-20a-20profound-20loss-20in-20old-20mice.-20Whether-20age-2Drelated-20immune-20disfunctions-20influence-20life-20span-20and-20tumor-20incidence-20has-20been-20examined-20in-20mice-20genetically-20selected-20for-20high-20or-20low-20antibody-20responsiveness.-20It-20has-20been-20found-20that-20genetic-20selection-20of-20vigorous-20antibody-20responses-20in-20most-20cases-20produces-20mice-20with-20longer-20life-20span-20and-20lower-20lymphoma-20incidence.-20Moreover%2C-20the-20results-20of-20genetic-20segregation-20experiments-20indicate-20that-20antibody-20responsiveness-20and-20life-20span-20are-20polygenic-20traits-20regulated-20by-20a-20small-20number-20of-20the-20same-20or-20closely-20linked-20loci.-20Mice-20genetically-20selected-20for-20high-20or-20low-20mitotic-20responsiveness-20to-20PHA-20exhibit-20low-20or-20high-20tumor-20incidence%2C-20respectively%2C-20but-20no-20difference-20in-20life-20span%2C-20suggesting-20that-20T-2Dcell-20activity-20is-20restricted-20to-20immune-20surveillance-20of-20neoplastic-20transformation.-20Studies-20on-20mice-20genetically-20selected-20for-20resistance-20or-20sensitivity-20to-20chemical-20carcinogenesis-20have-20uncovered-20loci-20that-20control-20both-20resistance-20to-20tumor-20induction-20and-20longevity-20while-20have-20no-20effects-20on-20immunity-20and-20disease-20incidence.-20Thus%2C-20the-20relative-20role-20of-20the-20immune-20system-20in-20conditioning-20the-20duration-20and-20the-20biological-20quality-20of-20life-20remains-20to-20be-20determined." contains a listed "%" character as part of the property label and has therefore been classified as invalid.

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