"%3AAbstract%2FAlthough-20many-20genetic-20factors-20and-20lifestyle-20interventions-20are-20known-20to-20affect-20the-20mean-20lifespan-20of-20animal-20populations%2C-20the-20physiological-20variation-20displayed-20by-20inspaniduals-20across-20their-20lifespans-20remains-20largely-20uncharacterized.-20Here%2C-20we-20use-20a-20custom-20culture-20apparatus-20to-20continuously-20monitor-20five-20aspects-20of-20aging-20physiology-20across-20hundreds-20of-20isolated-20Caenorhabditis-20elegans-20inspaniduals-20kept-20in-20a-20constant-20environment-20from-20hatching-20until-20death.-20Aggregating-20these-20measurements-20into-20an-20overall-20estimate-20of-20senescence%2C-20we-20find-20two-20chief-20differences-20between-20longer-2D-20and-20shorter-2Dlived-20inspaniduals.-20First%2C-20though-20long-2D-20and-20short-2Dlived-20inspaniduals-20are-20physiologically-20equivalent-20in-20early-20adulthood%2C-20longer-2Dlived-20inspaniduals-20experience-20a-20lower-20rate-20of-20physiological-20decline-20throughout%C2%A0life.-20Second%2C-20and-20counter-2Dintuitively%2C-20long-2Dlived-20inspaniduals-20have-20a-20disproportionately-20extended-20%E2%80%9Ctwilight%E2%80%9D-20period-20of-20low-20physiological-20function.-20While%C2%A0longer-2Dlived-20inspaniduals-20experience-20more-20overall-20days-20of-20good-20health%2C-20their-20proportion-20of-20good-20to-20bad-20health%2C-20and-20thus-20their-20average-20quality-20of-20life%2C-20is-20systematically-20lower-20than-20that-20of-20shorter-2Dlived-20inspaniduals.-20We-20conclude-20that%2C-20within-20a-20homogeneous-20population-20reared-20under-20constant-20conditions%2C-20the-20period-20of-20early-2Dlife-20good-20health-20is-20comparatively-20uniform%2C-20and-20the-20most-20plastic-20period-20in-20the-20aging-20process-20is-20end-2Dof-2Dlife-20senescence." contains a listed "%" character as part of the property label and has therefore been classified as invalid.

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