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• Aging in Single-celled Organisms: from Bacteria to the Whole Tree of Life/MatteoOsella  + (- General disagreement on the definitions … - General disagreement on the definitions of aging and senescence. It does not seem a purely semantic problem, but reveals the lack of universally accepted essential conditions to define the aging process.</br></br>Example: Role of asymmetry (necessary condition or not) in the cellular division process for the emergence of aging. </br></br>- Discussion on the more appropriate measure of time to observe aging of living things.... The intrinsic timescale of different organisms (for example doubling time in fast-growing conditions) and the timescale fixed by the environment (e.g. feast and famine cycles) should be taken into account. </br></br>[interesting parallel with the approximately constant lifespan of mammals if measured in heart beats shown by G.West]</br></br>- In several different systems the hazard rate (for cell division or for death) shows an exponential increase followed by a plateu (e.g. in mortality rate in E.coli shown by Uli and from Lindner group) . Different theoretical models can reproduce such a trend. Is there a way to do model selection?</br></br>- Need for measurements of metabolic rate in bacteria in order to build a complete phenomenological theory of resource partitioning and its relations with growth and mass. An extension of existing theories built on data based on balanced exponential growth probably need to include survival and the cost of maintenance... survival and the cost of maintenance...)

• Aging in Single-celled Organisms: from Bacteria to the Whole Tree of Life/MatteoOsella  +