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- Aging and Adaptation in Infectious Diseases II/Session II: Immune System: Aging and Heterogeneity#Original antigenic sin and antigenic maps + (Antigenic mapping is an important techniqu … Antigenic mapping is an important technique used measure and visualize differences between viruses, but understanding how these maps change given immune system variation between individuals remains challenging. Do the immune systems of different individuals see the same virus differently? How does this perspective change as individuals age and experience different sets of viruses in different orders? We briefly touch on some approaches we've taken to answer these questions and suggest how exposure history might affect both individual immune responses and epidemiological patterns. esponses and epidemiological patterns. )