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COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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What is Sleep?/ElizabethKlerman

From Complex Time

Notes by user Elizabeth Klerman (Harvard Medical School) for What is Sleep?

Post-meeting Reflection

1+ paragraphs on any combination of the following:

  • Presentation highlights
  • Open questions that came up
  • How your perspective changed
  • Impact on your own work
  • e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group
  • Add information/discussion about non-brain "functions" of sleep (e.g., metabolism, immune function) with their time scales
  • Add Other brain "functions" of sleep to include are: mood/psychiatry; objective neurobehavioral performance; "cleaning" of toxic substances (glymphatics); neurochemistry
  • What are target/pivot points for changing some aspect of sleep?
  • How to define and then study sleep "need"? Is it different for each function? with age? How does it interact with sleep duration or timing of sleep?
  • Feedback between sleep and circadian rhythms; not just one way circadian-> sleep
  • Two comments from discussion:
    • Comment: Frame the “needs” of sleep not as competitive with each other but as parallel.
    • Comment: Not all functions of sleep bring you back to where you were before; some are to bring to a new state (e.g., learning, immune)

Reference material notes

Some examples:

  • Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
  • Here is a free tool for calculating [ABC] (insert link)
  • This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
  • Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).

Reference Materials

Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
Genetics of the human circadian clock and sleep homeostat Ashbrook, Krystal, Fu, Ptacek 2019 0 0
Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans S. H. Strogatz, R. E. Kronauer, C. A. Czeisler Sleep 1986 0 0
Peak of circadian melatonin rhythm occurs later within the sleep of older subjects Jeanne F. Duffy, Jamie M. Zeitzer, David W. Rimmer, Elizabeth B. Klerman, Derk Jan Dijk, Charles A. Czeisler American Journal of Physiology - Endocrinology and Metabolism 2002 0 0
Entrainment of the human circadian clock to the natural light-dark cycle Kenneth P. Wright, Andrew W. McHill, Brian R. Birks, Brandon R. Griffin, Thomas Rusterholz, Evan D. Chinoy Current Biology 2013 0 0
Macroscopic Models for Human Circadian Rhythms 0 0
Simulations of light effects on the human circadian pacemaker: Implications for assessment of intrinsic period Elizabeth B. Klerman, Derk Jan Dijk, Richard E. Kronauer, Charles A. Czeisler American Journal of Physiology - Regulatory Integrative and Comparative Physiology 1996 0 0
Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker Melissa A. St. Hilaire, Elizabeth B. Klerman, Sat Bir S. Khalsa, Kenneth P. Wright, Charles A. Czeisler, Richard E. Kronauer Journal of Theoretical Biology 2007 0 0
Control of Mammalian Circadian Rhythm by CKI -Regulated Proteasome-Mediated PER2 Degradation E. J. Eide, M. F. Woolf, H. Kang, P. Woolf, W. Hurst, F. Camacho, E. L. Vielhaber, A. Giovanni, D. M. Virshup Molecular and Cellular Biology 2005 0 0
Mathematical model of the human circadian system with two interacting oscillators. R. E. Kronauer, C. A. Czeisler, S. F. Pilato, M. C. Moore-Ede, E. D. Weitzman The American journal of physiology 1982 0 0
Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day James K. Wyatt, Angela Ritz-De Cecco, Charles A. Czeisler, Derk Jan Dijk American Journal of Physiology - Regulatory Integrative and Comparative Physiology 1999 0 0
Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology Andrew J.K. Phillips, Charles A. Czeisler, Elizabeth B. Klerman Journal of Biological Rhythms 2011 0 0
High sensitivity and interindividual variability in the response of the human circadian system to evening light Andrew J.K. Phillips, Parisa Vidafar, Angus C. Burns, Elise M. McGlashan, Clare Anderson, Shantha M.W. Rajaratnam, Steven W. Lockley, Sean W. Cain Proceedings of the National Academy of Sciences of the United States of America 2019 0 0
Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans Derk Jan Dijk, Charles A. Czeisler Neuroscience Letters 1994 0 0
Review: On mathematical modeling of circadian rhythms, performance, and alertness Elizabeth B. Klerman, Melissa St Hilaire Journal of Biological Rhythms 2007 0 0
Are individual differences in sleep and circadian timing amplified by use of artificial light sources? Krithika Swaminathan, Elizabeth B. Klerman, Andrew J.K. Phillips Journal of Biological Rhythms 2017 0 0
A two process model of sleep regulation A. A. Borbely Human Neurobiology 1982 0 0
Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range Richard E. Kronauer, Megan E. Jewett, Daniel B. Forger Journal of Biological Rhythms 1999 0 0
Timing of Sleep and Its Relationship with the Endogenous Melatonin Rhythm Tracey L. Sletten, Simon Vincenzi, Jennifer R. Redman, Steven W. Lockley, Shantha M. W. Rajaratnam Frontiers in Neurology 2010 0 0
An exploration of the temporal dynamics Kronauer, St. Hilare, Rahman, Czeisler, Klerman J Biol Rhythms 2019 0 0
A quantitative model for the effects of light on the amplitude and phase of the deep circadian pacemaker based on human data Richard E. Kronauer 0 0
An opposite role for tau in circadian rhythms revealed by mathematical modeling Monica Gallego, Erik J. Eide, Margaret F. Woolf, David M. Virshup, Daniel B. Forger Proceedings of the National Academy of Sciences of the United States of America 2006 0 0
A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period Min Zhou, Jae Kyoung Kim, Gracie Wee Ling Eng, Daniel B. Forger, David M. Virshup Molecular Cell 2015 0 0
A Simpler Model of the Human Circadian Pacemaker Daniel B. Forger, Megan E. Jewett, Richard E. Kronauer Journal of Biological Rhythms 1999 0 0
Mammalian sleep dynamics: How diverse features arise from a common physiological framework Andrew J.K. Phillips, Peter A. Robinson, David J. Kedziora, Romesh G. Abeysuriya PLoS Computational Biology 2010 0 0
Circadian phenotype impacts the brain's resting-state functional connectivity, attentional performance, and sleepiness Elise R. Facer-Childs, Brunno M. Campos, Benita Middleton, Debra J. Skene, Andrew P. Bagshaw Sleep 2019 0 0
Circadian pacemaker interferes with sleep onset at specific times each day: Role in insomnia S. H. Strogatz, R. E. Kronauer, C. A. Czeisler American Journal of Physiology - Regulatory Integrative and Comparative Physiology 1987 0 0
Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans Kenneth P. Wright, Claude Gronfier, Jeanne F. Duffy, Charles A. Czeisler Journal of Biological Rhythms 2005 0 0
Comparing the Morningness-Eveningness Questionnaire and Munich ChronoType Questionnaire to the dim light melatonin onset Thomas Kantermann, Haein Sung, Helen J. Burgess Journal of Biological Rhythms 2015 0 1
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms Derk Jan Dijk, Jeanne F. Duffy, Eymard Kiel, Theresa L. Shanahan, Charles A. Czeisler Journal of Physiology 1999 0 0
Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans Joshua J. Gooley, Kyle Chamberlain, Kurt A. Smith, Sat Bir S. Khalsa, Shantha M.W. Rajaratnam, Eliza Van Reen, Jamie M. Zeitzer, Charles A. Czeisler, Steven W. Lockley Journal of Clinical Endocrinology and Metabolism 2011 0 0