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Hallmarks of Biological Failure/BernieCrespi

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Notes by user Bernie Crespi (Simon Fraser Univ.) for Hallmarks of Biological Failure

Post-meeting Reflection

1+ paragraphs on any combination of the following:

  • Presentation highlights
  • Open questions that came up
  • How your perspective changed
  • Impact on your own work
  • e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group

(1) General problem/question

DNA/RNA/proteins - cells - cell-to-cell interactions - tissues - organs - organ systems - whole organism - groups of related organisms as in colony - community including non-relatives

how/why does senescence occur at these different levels, in the contexts of antagonistic pleiotropy and mutation accumulation? does balance of early benefits vs later costs vary across these levels and systems?

does the complexity/stability/entropy of the system matter? how?

why does senescence accelerate exponentially in humans - synergisms between failure types/levels? why up so fast around age 60-65 in particular (later for women)-becoming less useful as a helper/contributor/transfer-er then, and are being 'replaced' these roles by next generation?

(2) Caloric restriction - reduces deleterious aging effects on health but does not lengthen lifespan if started after adulthood - why now? increases investment in maintenance, reduces growth and reproduction, based on energy, thus mitochondria

all cells use energy - does energy restriction impact some cells/systems more (eg brain if not fully protected); or are all systems just ramped down - how does this impact on disease risks, exactly - do diseases require more energy? or are fewer mistakes/mutations made?

(3) Single cell talk p21. Is this work key to cancer biology in that tumor suppressor functions being lost leads to all cells just keeping reproducting? can one show that senescent cells are less likely to transform, using this system?

Reference material notes

Some examples:

  • Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
  • Here is a free tool for calculating [ABC] (insert link)
  • This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
  • Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).

Reference Materials