What is Sleep?/ElizabethKlerman
From Complex Time
Notes by user Elizabeth Klerman (Harvard Medical School) for What is Sleep?
1+ paragraphs on any combination of the following:
- Presentation highlights
- Open questions that came up
- How your perspective changed
- Impact on your own work
- e.g. the discussion on [A] that we are having reminds me of [B] conference/[C] initiative/[D] funding call-for-proposal/[E] research group
- Add information/discussion about non-brain "functions" of sleep (e.g., metabolism, immune function) with their time scales
- Add Other brain "functions" of sleep to include are: mood/psychiatry; objective neurobehavioral performance; "cleaning" of toxic substances (glymphatics); neurochemistry
- What are target/pivot points for changing some aspect of sleep?
- How to define and then study sleep "need"? Is it different for each function? with age? How does it interact with sleep duration or timing of sleep?
- Feedback between sleep and circadian rhythms; not just one way circadian-> sleep
- Two comments from discussion:
- Comment: Frame the “needs” of sleep not as competitive with each other but as parallel.
- Comment: Not all functions of sleep bring you back to where you were before; some are to bring to a new state (e.g., learning, immune)
Reference material notes
- Here is [A] database on [B] that I pull data from to do [C] analysis that might be of interest to this group (insert link).
- Here is a free tool for calculating [ABC] (insert link)
- This painting/sculpture/forms of artwork is emblematic to our discussion on [X]!
- Schwartz et al. 2017 offers a review on [ABC] migration as relate to climatic factors (add the reference as well).
|Title||Author name||Source name||Year||Citation count From Scopus. Refreshed every 5 days.||Page views||Related file|
|Review: On mathematical modeling of circadian rhythms, performance, and alertness||Elizabeth B. Klerman, Melissa St Hilaire||Journal of Biological Rhythms||2007||0||0|
|A two process model of sleep regulation||A. A. Borbely||Human Neurobiology||1982||0||3|
|Mathematical model of the human circadian system with two interacting oscillators.||R. E. Kronauer, C. A. Czeisler, S. F. Pilato, M. C. Moore-Ede, E. D. Weitzman||The American journal of physiology||1982||0||2|
|Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans||S. H. Strogatz, R. E. Kronauer, C. A. Czeisler||Sleep||1986||0||0|
|Circadian pacemaker interferes with sleep onset at specific times each day: Role in insomnia||S. H. Strogatz, R. E. Kronauer, C. A. Czeisler||American Journal of Physiology - Regulatory Integrative and Comparative Physiology||1987||0||0|
|A quantitative model for the effects of light on the amplitude and phase of the deep circadian pacemaker based on human data||Richard E. Kronauer||0||11|
|Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans||Derk Jan Dijk, Charles A. Czeisler||Neuroscience Letters||1994||0||1|
|Simulations of light effects on the human circadian pacemaker: Implications for assessment of intrinsic period||Elizabeth B. Klerman, Derk Jan Dijk, Richard E. Kronauer, Charles A. Czeisler||American Journal of Physiology - Regulatory Integrative and Comparative Physiology||1996||0||0|
|Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms||Derk Jan Dijk, Jeanne F. Duffy, Eymard Kiel, Theresa L. Shanahan, Charles A. Czeisler||Journal of Physiology||1999||0||0|
|A Simpler Model of the Human Circadian Pacemaker||Daniel B. Forger, Megan E. Jewett, Richard E. Kronauer||Journal of Biological Rhythms||1999||0||1|
|Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range||Richard E. Kronauer, Megan E. Jewett, Daniel B. Forger||Journal of Biological Rhythms||1999||0||1|
|Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day||James K. Wyatt, Angela Ritz-De Cecco, Charles A. Czeisler, Derk Jan Dijk||American Journal of Physiology - Regulatory Integrative and Comparative Physiology||1999||0||0|
|Peak of circadian melatonin rhythm occurs later within the sleep of older subjects||Jeanne F. Duffy, Jamie M. Zeitzer, David W. Rimmer, Elizabeth B. Klerman, Derk Jan Dijk, Charles A. Czeisler||American Journal of Physiology - Endocrinology and Metabolism||2002||0||1|
|Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans||Kenneth P. Wright, Claude Gronfier, Jeanne F. Duffy, Charles A. Czeisler||Journal of Biological Rhythms||2005||0||1|
|An opposite role for tau in circadian rhythms revealed by mathematical modeling||Monica Gallego, Erik J. Eide, Margaret F. Woolf, David M. Virshup, Daniel B. Forger||Proceedings of the National Academy of Sciences of the United States of America||2006||0||0|
|Macroscopic Models for Human Circadian Rhythms||0||0|
|Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker||Melissa A. St. Hilaire, Elizabeth B. Klerman, Sat Bir S. Khalsa, Kenneth P. Wright, Charles A. Czeisler, Richard E. Kronauer||Journal of Theoretical Biology||2007||0||0|
|Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans||Joshua J. Gooley, Kyle Chamberlain, Kurt A. Smith, Sat Bir S. Khalsa, Shantha M.W. Rajaratnam, Eliza Van Reen, Jamie M. Zeitzer, Charles A. Czeisler, Steven W. Lockley||Journal of Clinical Endocrinology and Metabolism||2011||0||1|
|Mammalian sleep dynamics: How diverse features arise from a common physiological framework||Andrew J.K. Phillips, Peter A. Robinson, David J. Kedziora, Romesh G. Abeysuriya||PLoS Computational Biology||2010||0||0|
|Timing of Sleep and Its Relationship with the Endogenous Melatonin Rhythm||Tracey L. Sletten, Simon Vincenzi, Jennifer R. Redman, Steven W. Lockley, Shantha M. W. Rajaratnam||Frontiers in Neurology||2010||0||0|
|Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology||Andrew J.K. Phillips, Charles A. Czeisler, Elizabeth B. Klerman||Journal of Biological Rhythms||2011||0||0|
|Entrainment of the human circadian clock to the natural light-dark cycle||Kenneth P. Wright, Andrew W. McHill, Brian R. Birks, Brandon R. Griffin, Thomas Rusterholz, Evan D. Chinoy||Current Biology||2013||0||0|
|Comparing the Morningness-Eveningness Questionnaire and Munich ChronoType Questionnaire to the dim light melatonin onset||Thomas Kantermann, Haein Sung, Helen J. Burgess||Journal of Biological Rhythms||2015||0||4|
|A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period||Min Zhou, Jae Kyoung Kim, Gracie Wee Ling Eng, Daniel B. Forger, David M. Virshup||Molecular Cell||2015||0||0|
|Are individual differences in sleep and circadian timing amplified by use of artificial light sources?||Krithika Swaminathan, Elizabeth B. Klerman, Andrew J.K. Phillips||Journal of Biological Rhythms||2017||0||0|
|Control of Mammalian Circadian Rhythm by CKI -Regulated Proteasome-Mediated PER2 Degradation||E. J. Eide, M. F. Woolf, H. Kang, P. Woolf, W. Hurst, F. Camacho, E. L. Vielhaber, A. Giovanni, D. M. Virshup||Molecular and Cellular Biology||2005||0||1|
|Genetics of the human circadian clock and sleep homeostat||Ashbrook, Krystal, Fu, Ptacek||2019||0||2|
|Circadian phenotype impacts the brain's resting-state functional connectivity, attentional performance, and sleepiness||Elise R. Facer-Childs, Brunno M. Campos, Benita Middleton, Debra J. Skene, Andrew P. Bagshaw||Sleep||2019||0||0|
|An exploration of the temporal dynamics||Kronauer, St. Hilare, Rahman, Czeisler, Klerman||J Biol Rhythms||2019||0||0|
|High sensitivity and interindividual variability in the response of the human circadian system to evening light||Andrew J.K. Phillips, Parisa Vidafar, Angus C. Burns, Elise M. McGlashan, Clare Anderson, Shantha M.W. Rajaratnam, Steven W. Lockley, Sean W. Cain||Proceedings of the National Academy of Sciences of the United States of America||2019||0||2|