Santa Fe Institute Collaboration Platform

COMPLEX TIME: Adaptation, Aging, & Arrow of Time

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Contact: Caitlin Lorraine McShea, Program Manager, cmcshea@santafe.edu

Aging and Adaptation in Infectious Diseases/Session IV: Complex Rhythms, environment, and aging in epidemiology

From Complex Time

July 27, 2018
1:00 pm - 3:00 pm

Chair

David Schneider (Stanford)

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Sub-items

Social gradients in nonhuman primates: linking social status to immune gene regulation
Presenter
Jenny Tung (Duke Univ.)


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Title Author name Source name Year Citation count From Scopus. Refreshed every 5 days. Page views Related file
Social status alters immune regulation and response to infection in macaques Noah Snyder-Mackler, Joaquín Sanz, Jordan N. Kohn, Jessica F. Brinkworth, Shauna Morrow, Amanda O. Shaver, Jean Christophe Grenier, Roger Pique-Regi, Zachary P. Johnson, Mark E. Wilson, Luis B. Barreiro, Jenny Tung Science 2016 105 25
Infectious diseases across scales, circadian rhythms: Anticipating Complex Time
Presenter
Micaela Martinez (Columbia Univ.)

Abstract

The meeting is composed of expert disease dynamicsmodelers and disease ecologists; thus, my presentation will be focused on chronobiology. Specifically, I will review new data regarding circadian and circannual rhythms in humans and mouse models.

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Insights into aging and pathogens from allometrically scaled models for host-parasite systems
Presenter
Andrew P. Dobson (Princeton)

Abstract

Assemble a talk that describes non-human examples of how host exposure and response to pathogens and disease changes with age.

Describe ways of quantifying age-dependent changes in exposure.

Discuss possible dynamic consequences in variation in duration of incubation and infectivity with age.

Describe models for parasitic nematodes of different sizes living as a community of worms in hosts of different sizes.

Illustrate recent work with Ian Hatton on body size scaling of vital rates from Algae to Elephants - use this to suggest we could use this scaling for models of immune system in mammals (from bats and mice to elephants and whales).

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Andrew P. Dobson (Princeton) Link to the source page

Really interesting set of talks that blended into a good set of discussions on projects the group could work on. There will be a big emphasis on human immunity and how it first gains 'experience' and then breaks down with age.

I'm likely to focus my attention on developing body sized scaled models for immune system. These could be both fairly simple models for immunity mainly capturing differences between Type I and Type II immunity, but then expanding this to take Jean Carlson's model for human immunity and rescale elements of this with host body size and BMR.

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